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Alpha-Linolenic Acid - Europe PMC

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Last Updated: 10 May 2022

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Patterns of Alpha-Linolenic Acid Incorporation into Phospholipids in H4IIE Cells.

Alpha linolenic acid is an 18-carbon essential fatty acid present in plant-based foods and oils. Although much emphasis has been paid to the conversion of ALA to long chain polyunsaturated fatty acids, other pathways of ALA metabolism exist and may lead to the formation of other bioactive metabolites of ALA. The current research used a non-targeted metabolomics approach to identify ALA metabolites that are significantly enhanced by ALA therapy's treatment. Over the 12 hours after ALA therapy, we noticed subtle shifts in ALA incorporation into phospholipid classes and subclasses. These findings reveal that ALA incorporation into phospholipids is selective and support a metabolic hierarchy for ALA incorporation into specific phospholipids. Given the functionality of phospholipids based on their fatty acid composition, future studies will need to investigate the effects of ALA incorporation into specific phospholipids on cell function.

Source link: https://europepmc.org/article/MED/35461904

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions