* If you want to update the article please login/register
In brain tissues of patients with Alexander disease, a significant amount of insoluble GFAP was found in Rosenthal fiber fractions, which revealed a substantial amount of insoluble GFAP. These results reveal that GFAP assembly defects contribute to tissue pathology at the tissue level, and that modified filament assembly and properties as a result of GFAP mutation are important initiating factors in Alexander disease pathogenesis.
Source link: https://europepmc.org/article/MED/35511821
* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions