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Akt Erk Activation - Europe PMC

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Last Updated: 15 May 2022

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EGF/EGFR Promotes Salivary Adenoid Cystic Carcinoma Cell Malignant Neural Invasion via Activation of PI3K/AKT and MEK/ERK Signaling.

Salivary adenoid cystic carcinoma is one of the most common malignant gland tumors, and 32. 4-72 percent of SACC cases have neural invasion; however, the exact mechanism that underlies the high invasion risk of SACC remains unclear. The present study looked at the role of epidermal growth factor receptor in AKT inhibition- or mitogen-activated protein kinase-induced NI and epithelial-mesenchymal transition in SACC cells using EGFR, PI3K, and MEK inhibitors. Cell viability of SACC 83 cell viability was determined using an MTT assay, and a wound healing assay was used to determine cell migration. In a xenograft model in nude mice, the effects of EGFR, PI3K, and MEK inhibitors on tumor formation and NU was investigated. It was also shown that inhibition of EGFR reduces EMT in SACC by inhibiting the signaling of PI3K/AKT and MEK/ERK.

Source link: https://europepmc.org/article/MED/35410600


Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors.

paraphrasergic, and S1P receptor stimulation. We found a kinetic response kinetics related to histamine, 2-adrenergic, and S1P receptor stimulation in a ligand-dependent manner. We found that Gq mediated the ERK and Akt responses to histamine by using G-protein inhibitors. S1P-intuitive ERK and Akt were both strongly stimulated by S1P, resulting in significant heterogeneity at the single-cell level, especially for ERK and Akt. Cluster analysis of time series derived from 68,000 cells obtained under various conditions revealed several distinct populations of cells with similar response dynamics. The ERK's response dynamics to S1P revealed high heterogeneity, which was reduced by Gi's blockage.

Source link: https://europepmc.org/article/MED/35107584

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions