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AKT ERK Activation - Europe PMC

Summarized by Plex Scholar
Last Updated: 06 November 2022

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Increased Anxiety-like Behaviors in Adgra1 -/- Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways.

Adhesion G protein-coupled receptor A1 belongs to the G protein-coupled receptor family, and its physiological function is largely unknown. Adgra1 is widely and specifically expressed in the brain, meaning that Adgra1 is primarily expressed in the brain, meaning that Adgra1 may be involved in the regulation of neurological habits such as anxiety, depression, learning, and memory. ADGRA1 deficiency resulted in increased dendritic branching complexity and spine density, as shown by elevated expression levels of SYN and PSD95 in male mouse amygdalae. When compared to wt male mice, PI3K/AKT/GSK-3u03b2 and MEK/ERK in amygdalae of Adgra1-deficient male mice were aberrantly activated, according to us. Our results show an important suppressive role for ADGRA1 in anxiety regulation and synaptic function in amygdalae of male mice by regulating the PI3K/AKT/GSK-3000/u03b2/ERK-3u03b2 and MEK-ERK pathways, implicating a potential, therapeutic use in novel anti-anxiety drug manufacture.

Source link: https://europepmc.org/article/MED/36115515

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions