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AKT ERK Activation - Crossref

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Last Updated: 06 November 2022

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Differential role of dopamine D3 receptor through balanced modulation of Akt/mTOR and ERK 1/2 activity in the reactivation of cocaine rewarding memories evoked by psychological versus physiological stress

Abstract Stress is a common cause of cocaine use relapses. D3 receptor antagonists, according to further, preclinical results, are promising therapeutic tools to reduce cocaine reward and relapse. Because the reintroduction of cocaine-induced conditioned place preference evoked by emotional and physical strain, we investigated the impact of SB-277011-A, a D3R antagonist, on the functioning of Akt/mTOR and MEK/ERK 1/2 pathways in these areas. Corticosterone may be partially responsible for these variations, as we found high correlations between its prevalence and mTOR and/or Akt function in the BLA and DG of restrained animals receiving B-277011-A. Similarly, locomotor activity of animals receiving 48 mg/kg of the antagonist is highly correlated with p-mTOR/mTOR and p-ERK 1/2 /ERK 1/2 in the BLA during restraint- and tail pinch-induced cocaine-CPP relapse in cocaine-CPP, respectively.

Source link: https://doi.org/10.1101/2022.09.12.507553

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions