Advanced searches left 3/3

ADHD sign - Crossref

Summarized by Plex Scholar
Last Updated: 10 June 2022

* If you want to update the article please login/register

Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility

"Abstract Latrophilin-3 is a member of the adhesion G Protein Coupled Receptor subfamily," which aids in the formation and maintenance of neuronal networks by mediating intercellular adhesion by heterophilic interactions with transmembrane ligands. The ability of Lphn3 to maintain intercellular adhesion in a manner that was unique among ligands classes, but not dependent on ligand-receptor interaction parameters, indicating modified intrinsic receptor signaling characteristics. Our results point to Gu103b113 selective signaling defects as representing a disease-specific pathogenicity pathway that can be inherited by Lphn3 gene polymorphisms. This research reveals the intricate interplay between Lphn3 GPCR functions and the actin cytoskeleton in modulating neurodevelopmental cues related to ADHD etiology.

Source link: https://doi.org/10.1038/s41380-022-01537-3


Functional Connectivity based Brain Signatures of Behavioral Regulation in Children with ADHD, DCD and ADHD-DCD

"ABSTRACT Background Children with neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder often have trouble with behavioral control, which is often associated with daily life challenges. " ADHD is also present with Developmental Coordination Disorder (DCD), but no one is aware of BR in DCD. Given the danger of negative outcomes, gaining a better understanding of the brain mechanisms underlying BR in children with ADHD and/or DCD is essential. Multiple FC patterns were found with BR among all participants, as well as BR. Some FC patterns were linked to multiple BR subdomains, while others were limited to just one. The only difference in BR was found between children with ADHD and those without ADHD. FC discrepancies were also discovered between children with and without ADHD. Conclusions Our results show dimensional correlations between BR subdomain scores and whole-brain FC, demonstrating the possibility of these as well-brain FC in children with and without ADHD as brain-based signatures of BR in children with and without ADHD. ".

Source link: https://doi.org/10.1101/2020.04.06.20050013

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions