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An abundance of studies point to MPH's effectiveness in attenuating inattentive, hyperactive, and impulsive signs in children with ADHD. Despite its effectiveness, most children with ADHD who are prescribed MPH have poor continuity of care for a variety of reasons, including forgetting to administer the medication and delays getting refills. However, growing evidence shows that MPH's pharmacological activities may have long-term brain neurochemistry changes that persist beyond medication discontinuation. Across two recruitment agencies, 180 children diagnosed with ADHD will participate in two recruitment centers. Participants will be randomized to either discontinue MPH or remain on MPH for four weeks after undergoing a 4-week MPH titration trial and a 4-week MPH rehabilitation phase. We will investigate the effects of MPH suspension on behavioral, cognitive, and academic development in children with ADHD.
Source link: https://clinicaltrials.gov/ct2/show/NCT02293655
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