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ADHD - ClinicalTrials.gov

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Last Updated: 03 June 2022

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Better Sleep in Psychiatric Care - ADHD. A Pragmatic Within-group Pilot Study to Develop and Evaluate Effects and Feasibility of a CBT-based Manual for Treating Sleep Problems in Adult Patients With ADHD

"Treatment of choice for insomnia is cognitive behavioral therapy, but results for CBT-i in patients with ADHD and sleep difficulties are inconsistent, but CBT-i is lacking. " Patients at a pediatric clinic for ADHD receive CBT-i therapy from a consortium, and it is unclear if insomnia sufferers improve following this therapy. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT03852966


ADHD and Nutrition: The Influence of Omega-3 on ADHD Related Symptoms

"Children with ADHD are found to have low blood levels of omega-3 fatty acids that are not related to diet. " Poor cognition and behavior have been directly related to low omega-3 intakes. Trials have shown that omega-3 supplements can increase literacy and behavior in children with ADHD symptoms. The effect sizes found in meta analysis of placebo-controlled clinical trials on ADHD core symptoms are small to modest. In a report of adolescent mental health in North Norway between fish intake and hyperactivity, adolescents with a high intake demonstrated less hyperactivity than peers with a low intake in a 2003-2005 study. In addition, we are using whole marine oil from the zooplankton Calanus finmarchicus, which has a high amount of stearidonic acid in the form of EPA 18:3 n-3, which is a precursor to EPA. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02986672


Lifestyle Enhancement for ADHD Program (LEAP) Study 2

"Hypotheses being tested include: 1 LEAP is expected to be more effective in raising PA in children with ADHD in the short run and over a year, more so than standard BPT and 2 children randomized to LEAP, which will result in greater and more consistent improvement in clinical outcomes relative to benchmark BMT. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT04779333


Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)

"Attention Deficit Hyperactivity Disorder is one of the most common childhood disorders and the most common childhood neurodevelopmental disorder. " ADHD is caused by a combination of genetic and environmental causes, according to the general belief. The main aim of the study is to perform genetic and behavioral studies that will help identify the genetic factors in diagnosis, prognosis, severity, and pharmacological responses in ADHD patients. study has contributed to the understanding of ADHD and its underlying comorbidities, as the interaction of genetic, demographic, and environmental causes underpinning the risk of developing ADHD has been investigated since the beginning of the study in 2000; the extent to which these factors influence ADHD patients's response to pharmacological interventions; and the use of advanced genetic epidemiological tools with promise for use in clinical practice. In one of the first identified regions of strong genetic variation in chromosome 4q13. 2, the most notable scientific findings occurred in 2010 when the study team discovered LPHN3, a key gene implicating ADHD and comorbid conditions. Recent research has concentrated on identifying new areas of the genome linked to ADHD and identifying genetic variations implicated in ADHD's etiology and clinical manifestations. One of the study's key objectives is to provide a more concrete method to diagnose ADHD and to assess and predict prognosis as the current diagnosis of ADHD is based on subjective findings.

Source link: https://clinicaltrials.gov/ct2/show/NCT00046059


Efficacy of External Trigeminal Nerve Stimulation for Treatment of ADHD

"Trigeminal Nerve Stimulation," an FDA-approved, non-invasive minimal risk treatment of Attention-Deficit/Hyperactivity Disorder, gives the forehead a small amount of electrical stimulation during sleep and has been shown to elevate brain regions related to attention and impulse control. Across the two locations, we will screen up to 280 people to produce an overall report. Phase 1 is a 4-week double-blind, controlled trial of active vs. sham TNS in Phase 1. During sleep for four weeks, participants will begin using TNS as directed every night. EEG, as well as other cognitive tests, will be repeated at week 4 in the United States. Participants in Phase 2, who were not initially selected to sham, will receive active TNS for an additional four weeks, as well as continued weekly testing. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT05374187


Behavioral Activation To Reduce Problem Alcohol Use In College Students With ADHD

"College students with Attention-Deficit/Hyperactivity Disorder are particularly vulnerable to problematic alcohol use due to their developmentally-inappropriate levels of attention, hyperactivity, and impulsivity, as well as the lifestyle associated with life on a college campus. " Prior studies shows elevated rates of alcohol misuse and disorders among college students with ADHD; 47% of college students with ADHD meet lifetime alcohol use guidelines, while 23% met dependence requirements; as compared to 12% and 6% of college students from the general population, respectively. Despite the obvious evidence from emerging research pointing to the need for such interventions, there are currently no published controlled trials examining college students with ADHD and none specifically targeting AUDs in this population at any age. To support transportation to the university counseling center setting, it is essential to determine core treatment elements that are safe for treating AUDs and are developmentally appropriate for college students with ADHD, and that are developmentally appropriate for college students with ADHD. In a variety of situations, including college students with problematic drinking habits, a BA has been successfully applied to substance users. In the current report, the investigators will develop BA-based therapy that will increase student engagement in healthier, goal-directed activities, and reduce substance use and other risk factors among college students with ADHD. "BMI + BAAAD will be able to support college students with ADHD, as a result of reduced problematic alcohol use patterns increasing as compared to BMI + SC. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02829970


Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

"The overall aim of this research is to determine the changes in task-related neural activity related to ADHD and brain glutamate levels following methylphenidate therapy. " In adults with ADHD, this will be a double-blind crossover of methylphenidate and placebo.

Source link: https://clinicaltrials.gov/ct2/show/NCT04781972


Executive Function Enhanced Parent-Based Treatment for Children With ADHD and Overweight or Obesity

"Attention-Deficit Hyperactivity Disorder is one of the most common neurobehavioral disorders in children and is characterized by difficulties in Executive Function. " According to extensive studies, children with ADHD have higher rates of OW/OB in children with ADHD; therefore, children with OW/OB and ADHD have more difficulty with EF and achieving success in FBT. The aim of the current research is to develop a parent-based behavioral therapy supplemented with EF training in order to improve treatment outcomes for children with comorbid OW/OB and ADHD. This report may include a novel way to treat OW/OB in children with ADHD, as well as providing clinical advice regarding obesity management.

Source link: https://clinicaltrials.gov/ct2/show/NCT05165511


The Effect of Methylphenidate (Ritalin IR) Treatment in Familial Attention Deficit/Hyperactivity Disorder (ADHD)

"It was discovered that the first-degree families of ADHD patients had a higher risk of ADHD, 4-6 times more than the general population. " "Subjects will be in Ritalin IR for 4 weeks and complete multiple psychological and cognitive assessments at each time of the follow-up meeting. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT01554046


Increasing Motivation in Attention Deficit Hyperactivity Disorder (ADHD) Via Self-activation of Ventral Tegmental Area (VTA)

"The research includes a screening visit and four experimental task sessions to see if they meet the ADHD diagnostic criteria. " The following assessments will be administered at screening for ADHD: breath alcohol testing, urine drug screening, and urine cotinine testing will be included in the evaluation. Participants in the study of inclusion will then be scheduled for four fMRI sessions to explore and improve the ability to self-stimulate VTA activation. The experimental imaging task sessions will be held within a month frame and will consist of two types of runs: Test Runs and three Training Runs. In the absence of feedback, the Post-Test is intended to determine whether participants are more likely to self-induce VTA BOLD signals. Participants will begin and end each scanning session with a 2-minute resting state scan. The aim of the first run is to collect data in functional space in order to facilitate the VTA's probabilistic atlas' registration to functional space. Participants will be asked to count backwards during the Count trials. Participants with RTFF will be aided in raising their VTA BOLD signal during the next training runs. Participants in the Rest trials will be advised to rest and not think of anything in particular. The Cognitive Battery assessments will be repeated following the Post-Test each day, but without the subject out of the scanner. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02723708

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions