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Last Updated: 16 January 2022

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Does coronary calcium score add value to European SCORE in an asymptomatic population?

Abstract Background Despite being a controversial topic, several studies mention the use of Coronary Artery Calcification scoring in the cardiovascular risk prediction in the asymptomatic population. Adding CAC scores to European SCORE could raise the likelihood of MACE forecast, as well as cardiovascular risk stratification. Purpose Our study aims to investigate the effect of CAC severity in MACE prediction and comparison with SCORE, as well as estimate the additional value of CAC scores in cardiovascular risk stratification in a low-risk area and asymptomatic population. SCORE does not remain in the equation after a Cox regression for MACE occurrence, and the more severe severity of CAC elevated risk of MACE involvement with a high HR of 7. 943. Conclusion Our findings point to the importance of the CAC score in primary prevention and cardiovascular risk stratification, which leads to improved cardiovascular risk stratification. A CAC score in clinical training may have a prognostic effect on MACE prediction.

Source link: https://doi.org/10.1093/eurheartj/ehab724.2731


Examining transcranial random noise stimulation as an add-on treatment for persistent symptoms in schizophrenia (STIM’Zo): a study protocol for a multicentre, double-blind, randomized sham-controlled clinical trial

Abstract Background: One of three patients with schizophrenia failed to respond adequately to antipsychotics, causing debilitating signs such as auditory hallucinations and negative signs. Here, we conduct a randomized controlled trial determining the effectiveness of high-frequency random noise stimulation in the treatment of persistent/persistent symptoms of schizophrenia in patients with varying degrees of signs, cognitive dysfunctions, and illness duration. Methods in a double-blind, double-arm, multicentre study, 144 patients with schizophrenia and persistent signs despite the prescription of at least one antipsychotic drug, were randomly assigned to receive either active or sham hf-tRNs. Presented in a Way The findings of this trial will be the first step toward establishing the usefulness of hf-tRNs in schizophrenia whatever the stage of the disease or the level of treatment resistance. We hypothesize a long-term effect of active hf-tRNs on the severity of schizophrenia disorders as compared to sham.

Source link: https://doi.org/10.1186/s13063-021-05928-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions