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Acute - Europe PMC

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Last Updated: 26 September 2022

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Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.

Context Acute promyelocytic leukaemia is a malignant hematological tumor characterized by the presence of the promyelocytic leukaemia receptor A fusion protein, a fusion protein. Cinobufagin is one of the most common antitumor agents with antitumor properties, and it has antitumor capabilities. Object We investigated the effect and mechanism of CBG's action on NB4 and NB4-R1 cells. Methods and methods We investigated the efficiency of NB4 and NB4-R1 cells treated with cyclin D1, u03b2-catenin, cyclin D1, and c-myc expression for 12, 24, 40, and 48 h. After treatment with CBG for 24 h, and 48 h, we found c-myc and RTCP. For 24 h, the IC 50 values of NB4 and NB4-R1 cells treated with CBG were 45. 2 nM and 37. 9 nM, respectively. This report suggests a novel treatment approach for patients with APL, particularly those with ATRA-resistant APLs.

Source link: https://europepmc.org/article/MED/36121296


Urinary NGAL, IGFBP-7, and TIMP-2: novel biomarkers to predict contrast medium-induced acute kidney injury in children.

Background Serum creatinine is unreliable in detecting acute changes in kidney function. The aim of this research is to determine the success of the combination of urinary neutrophil gene expression factor binding protein-7, insulin-like growth factor binding protein-7, and tissue inhibitor of metalloproteinase-2 in children with CI-AKI. Whether they can diagnose CI-AKI early, the dynamic changes in urinary NGAL, IGFBP-7, and TIMP-2 levels in children with intravascular injection of contrast media were investigated to see whether they can diagnose CI-AKI early. When both urinary IGFBP-7 and TIMP-2 were used together, urinary [IGFBP-7][TIMP-2] at 0. 417 2 / 1000 was considered the cutoff value. NIGEAL, IGFBP-7, and TIMP-2 serum concentrations in children's urine after injections of contrast medium increased faster than SCr, and had a high clinical value for the early diagnosis of CI-AKI in children. The combination of IGFBP-7 and TIMP-2 was more effective than either analyte alone.

Source link: https://europepmc.org/article/MED/36120960


Decreased expression of HBA1 and HBB genes in acute myeloid leukemia patients and their inhibitory effects on growth of K562 cells.

Methods Quantitative real-time PCR was used to determine HBA1 and HBB expression in acute myeloid leukemia patients and AML cell lines. HBA1 and HBB genes were significantly reduced in acute myeloid leukemia patients and AML cell lines, according to HBA1 and HBB. In addition, in vitro experiments, overexpression of HBA1 and HBB retarded proliferation, resulted cell death, and suspended cell cycle progression, as in K562 cells.

Source link: https://europepmc.org/article/MED/36117408


An immune-related gene prognostic index for acute myeloid leukemia associated with regulatory T cells infiltration.

Acute myeloid leukemia is a malignant clonal disease characterized by abnormal growth of immature myeloid cells and bone marrow abnormality. T cells' anti-tumor immune response in the tumor microenvironment is largely suppressive. AML gene expression profiles of AML can be predicted using TCGA and GEO databases, using Treg immune-related genes. Patients in the high-risk group had a poorer OS in comparison to those in the low-risk group. Patients in the high-risk group also had a higher TP53 mutation rate, increased infiltration of Treg, higher immune escape potential, and less benefit from ICI therapy than the low-risk group, according to our study, which helped to clarify AML's immunological and molecular characteristics, predicted patient risk, and suggested a predictor of ICI therapy.

Source link: https://europepmc.org/article/MED/36102723


Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model.

To deliver Col via the transdermal route, we created a dissolvable Col-loaded microneedle with hyaluronic acid. To determine the pharmacokinetic profile, the pharmacokinetics of Col after Col-loaded MN were compared to those of Col solution gavage over 24 hours. After application, no skin irritation was present for three days. We found that 3. 36 percent more Col contained in MNs was delivered via the skin than that in gel in vitro, as well as moderate relative bioavailability in vivo. In an acute gout model in rats, the Col-loaded MN significantly reduced swollen knee joints and mechanical hypersensitivity. When acute gout occurred, the dissolvable Col-loaded MN array reduced inflammation and pain by topical application. Col-loaded MNs' gastrointestinal side effects is expected to optimize Col-loaded MNs' therapeutic effects and boost patient satisfaction by reducing the gastrointestinal side effects of Col-loaded MNs.

Source link: https://europepmc.org/article/MED/36101018


Tyrosine kinase inhibitors and reduced-dose chemotherapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia.

In adults with Philadelphia chromosome-positive acute lymphoblastic leukemia, the aim was to compare the effects of tyrosine kinase inhibitors in combination with reduced-dose chemotherapy, as well as those of standard induction chemotherapy, as well as the comparison of chemotherapy and transplantation. Methods: We retrospectively reviewed cases of Ph+ patients undergoing TKIs and combination chemotherapy. The patients were randomly assigned to either the TKIs with reduced-dose chemotherapy program or the TKIs with standard chemotherapy group. Results: The complete remission rate, large molecular response, molecular complete response, and early mortality rate among the TKIs with reduced-dose chemotherapy and the TKIs with standard chemotherapy group were similar. In the conventional chemotherapy regimen, the proportions of lung infections, bloodstream infections, patients with > 21 days of hospitalization, the total cost, transfusion charges, and antimicrobial expenses were higher than in the TKIs with reduced-dose chemotherapy group.

Source link: https://europepmc.org/article/MED/36083141


Frequency and clinical impact of WT1 mutations in the context of CEBPA-mutated acute myeloid leukemia.

Several studies have shown that mutations in the Wilms tumor 1 gene are present in adult acute myeloid leukemia. Methods We retrospectively assessed the prevalence and clinical consequences of WT1 mutations in 220 newly diagnosed AML patients with CEBPA mutations. In 29 of the 220 CEBPA mut AML patients tested, 30 WT1 mutations were found. WT1 mutations were found to be significantly more prevalent in AML patients with double-mutated CEBPA than in AML patients with single-mutated CEBPA. Patients with CEBPA dm AML patients with WT1 mutations had poor relapse-free survival, event-free survival, and overall survival compared to patients with CEBPA dm AML with WT1 mutations. Conclusion Our results showed that WT1 mutations are often found in CEBPA mut AML, especially in CEBPA dm AML. Patients with WT1 mutations who are CEBPA mut AML have a distinct pattern of comutations.

Source link: https://europepmc.org/article/MED/36066283


The anti-stress effect of taurine in fish: Assessments based on repeat acute stress and animal individuality

We find that repeated acute anxiety reduces energy consumption and display high behavioral plasticity, in order to know if taurine has an anti-stress effect on olive flounder with bold and shy coping style. Interestingly, taurine therapy reduced anxiety in the divergent behavioral styles: 1. In the hypothalamus and caudal neurosecretory system under stress, treatment with taurine reduced the plasma epinephrine, noreno-tropic hormone, and cortisol, as well as the expression of corticotropin-releasing hormone, urotensin I and urotensin II. Overall, our report shows that taurine can effectively increase anti-stress endurance and passivate stress response in flounder by varying stress axis.

Source link: https://europepmc.org/article/MED/IND607873337


Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment.

Acute myocardial infarction is one of the most common ischemic heart disorders. However, a significant reason of treatment failure is a lack of adequate drug concentration. We built a CAL and TAN combined lipid-polymer nano-system, and RGD was added to the platform to achieve RGD-CAL/TAN NS. In AMI rats' model, the AMI therapy capabilities of the devices was tested. The number of MTP/RGD-CAL/TAN NS was 170. 2 5. 6 nm, with a surface charge of -18. 9 1. 9 mV. According to MTP/RGD/UT/TAN NS, the area under the curve and blood circulation half-life was 178. 86. 62 mmL and 0. 47 h, respectively. MTP/RGD-CAL/TAN NS had the largest infarct size reduction effect of 22. 9%, with a 22. 9% reduction in MTP/RGD-CAL/TAN NS. The highest heart rate and largest infarct size reduction effect was seen on MTP/RGD-CAL/TAN NS, which may have been used as a promising therapy for cardiovascular disease treatment.

Source link: https://europepmc.org/article/MED/36047255


Diagnosis and treatment of acute lymphoblastic leukemia in Latin America.

In Latin America, the aim is to discuss the current and challenges involved with acute lymphoblastic leukemia care. Methods This paper summarizes various findings obtained from studies on diagnostic methods and treatment strategies in adult patients in Latin American Countries. Nevertheless, major barriers to effective treatment in Latin America and LMIC remain: poor adherence, abandonment of therapy, and a lack of supportive therapy and new therapeutic agents.

Source link: https://europepmc.org/article/MED/36040187

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions