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ACT Test - Springer Nature

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Last Updated: 16 January 2022

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Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach

For creating mixtures of similar acting substances, the valproic acid structural analogs 2-propylhexanoic acid and 2-propylhexanoic acid were selected, while a combination of the pesticidal active substance clothianidin was selected for creating mixtures of dissimilarly acting compounds. The existing steatosis AOP can still be improved with respect to the early key event of gene expression in order to reflect the multitude of molecular mechanisms that underlie the adverse reaction, according to gene expression results.

Source link: https://doi.org/10.1007/s00204-021-03182-1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions