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For creating mixtures of similar acting substances, the valproic acid structural analogs 2-propylhexanoic acid and 2-propylhexanoic acid were selected, while a combination of the pesticidal active substance clothianidin was selected for creating mixtures of dissimilarly acting compounds. The existing steatosis AOP can still be improved with respect to the early key event of gene expression in order to reflect the multitude of molecular mechanisms that underlie the adverse reaction, according to gene expression results.
Source link: https://doi.org/10.1007/s00204-021-03182-1
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