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Aconitic Acid - Crossref

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Last Updated: 10 May 2022

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Equilibrium & kinetic studies of reactive extraction of trans- aconitic acid using sunflower oil with tri- n -octylamine

n-octylamine as an extractant and sunflower oil as a diluent was tested in order to create an effective extraction system for biochemically produced trans aconitic acid from fermentation broth; equilibrium and kinetics of reactive extraction of TAH from aqueous solutions were investigated using tri-n -octylamine as an extractant and a diluent. In a regime 1, i. e. , Kinetics experiments were carried out in Lewis type stirred cell, and results revealed that reaction between TAH and TOA in sunflower oil fall in regime 1, i. e.

Source link: https://doi.org/10.1515/ijcre-2021-0107


Experimental visceral leishmaniasis: role of trans-aconitic acid in combined chemotherapy

TAA's influence on TAA, along with other antileishmanial drugs, has been investigated in macrophage cultures of Leishmania donovani. TAA's effectiveness in combined chemotherapy of experimental visceral leishmaniasis has also been tested, as well as those of commonly used antileishmanial agents such as sodium stichrome, pentamidine, and allopurinol. Transformation of L. donovani amastigotes to promastigotes by 95 percent was halted by TAA's combination of pentamidine, allopurinol, and sodium stibogluconate inhibited change by 99, and 98 percent, respectively, with pentamidine, alopurinol, and sodium stibogluconate. TAA in combination with sodium stibogluconate, pentamidine, and allopurinol reduced the spleen parasite load by 98, 98. 9, and 97%, respectively, in experimental visceral leishmaniasis in hamsters. TAA at a dose of 200 mg/kg body weight per day reduced the spleen parasite load by 73. 5%, and TAA in combination with sodium stiboglucetam.

Source link: https://doi.org/10.1128/aac.37.11.2459

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions