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ACE Inhibitor - Europe PMC

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Last Updated: 10 August 2022

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Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes.

Angioedema is a rare but potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, and it could be life-threatening. In addition, recent case findings reveal that some ACEi/ARB-induced angioedema patients may have pathogenic HAE variants. In a large cohort of ACEi/ARB-induced angioedema and HAE genes by systematic molecular genetic profiling, a large cohort of ACEi/ARB-induced angioedema patients was found to have the potential relationship between ACEi/ARB-induced angioedema and HAE genes. In 212 ACEi/ARB-induced angioedema patients recruited in Germany/Austria, Sweden, and Denmark, as well as in 352 controls from a German cohort, five HAE-related genes were re-sequencing of five HAE-related genes was conducted. Variant p. R523W was found solely in controls and has previously been found with reduced plasminogen, a precursor of plasmin which is directly involved in bradykinin manufacturing. In addition, we were unable to establish a significant relationship between ACEi/ARB-induced angioedema and other gene variants in the analyzed genes.

Source link: https://europepmc.org/article/MED/35923707

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions