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AAA - PubMed

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Last Updated: 21 July 2022

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FLOWERING REPRESSOR AAA+ ATPase 1 is a novel regulator of perennial flowering in Arabis alpina.

Arabis alpina is a polycarpic perennial in which PERTINUAL FLOWERING1 controls flowering and perennial traits in a vernalization-dependent manner. Other flowering time regulators were involved in PEP1-parallel pathways, according to Mutagenesis screens of the pep1 mutant. We also characterized our role in A. thaliana using CRISPR and in A. alpina by introgressing mutant alleles into wild type background. On the contrary, A. thaliana CRISPR lines produced weak flowering phenotypes. AaFRAT1 plays a role in flowering time control and A. alpina's perennial growth habit.

Source link: https://doi.org/10.1111/nph.18374


Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis.

Here, we discuss the proposed roles for Pex1/Pex6 in peroxisome biogenesis and degradation, as well as how the unraveling of new substrates contributes to peroxisome homeostasis. Since mutations in PEX1 and PEX6 are responsible for the majority of reported cases of peroxisome biogenesis disorders, such as Zellweger syndrome, the majority of known instances of peroxisome biogenesis disorders such as Zellweger syndrome, analysis into Pex1/Pex6 organization and function are crucial for understanding peroxisome biogenesis disorders in human health and disease.

Source link: https://doi.org/10.3390/cells11132067


Fast dynamics shape the function of the AAA+ machine ClpB: lessons from single-molecule FRET spectroscopy.

We explore how ultrafast domain motions relate to the operation of caseinolytic peptide B, a AAA+ disaggregation unit, in this State of the Art Review. ClpB is a large hexameric protein that works with cell chaperone machinery to remove protein chains from aggregates. In the absence of a substrate protein, motions of the N-terminal domain were found to restrict the M domain's conformational space, inhibiting it from tilting and sparking ClpB. Based on our findings, we propose a two-time-scale model for ClpB's operation, in which fast conformational dynamics influence slower functional steps, which are determined by ATP hydrolysis time. Future work on this and other proteins is expected to shed further light on the role of ultrafast dynamics on protein function.

Source link: https://doi.org/10.1111/febs.16539


Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence.

By far the most common cause of cancer deaths worldwide, lung cancer is by far the most common cause of cancer deaths, and 85 percent of patients are diagnosed with non-small cell lung cancer, which is also extremely difficult to treat. Here, we introduce a new Skp2 inhibitor AAA-237 that binds to Skp2 protein and blocks the cell proliferation of the NSCLC cells. However, we found that treating a high AAA-237 concentration for a longer time may lead to apoptosis of NSCLC cells, and that treatment with a lower AAA-237 concentration for a longer period could lead to NSCLC cell senescence.

Source link: https://doi.org/10.1016/j.phrs.2022.106259


Emphasis on Early Identification of Risk Factors to Curtail High Mortality Involved With Ischemic Colitis (IC) After Abdominal Aortic Aneurysm (AAA) Repair.

Ischemic colitis is one of the most common problems after abdominal aortic aneurysm repair. The two most common methods for treating aneurysms are open repair and endovascular aneurysm repair, and both of these procedures have their implications on the development of IC. Although the incidence of IC increased after open repair was higher after open repair, the hospital held more patients with ruptured aneurysms, emergency services, and patients in shock. In the same vein, a substantial number of patients with ruptured aneurysms developed IC. Medical advancements and minimally invasive technologies have greatly enhanced the quality of care and operation success, but researchers have yet to establish a statistically significant relationship in the prevention of postoperative IC. This can be achieved by being aware of imminent signs and symptoms, especially in patients with risk factors and being proactive in medical management.

Source link: https://doi.org/10.7759/cureus.23492


AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.

We produced knock-in mice carrying an A232E mutation in VCP, a common human VCP pathogenic variant. To investigate VCP's pathophysiological role in metabolic disorders, we generated knock-in mice carrying an A232E mutation in VCP. In A232E/+ mice, a co-immunoprecipitation study in wildtype mice revealed interactions of VCP with SREBP1 and a rhomboid protease, RHBDL4, in the liver, and these interactions were diminished. SREBP1's unique proteolytic processing pathway is shown in the present study, which may lead to the development of new therapeutic approaches to treat fatty liver disease.

Source link: https://doi.org/10.1016/j.jbc.2022.101936

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions