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AAA - Europe PMC

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Last Updated: 21 July 2022

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The AAA Get Fit Trial: A randomised controlled trial of exercise to improve fitness in patients with abdominal aortic aneurysm.

Objectives Objectives: Acute abdominal aortic aneurysm has a mortality risk of up to 80%. Patients on AAA surveillance were randomly assigned to either; a 24-week community exercise program CEP with the choice of gym or home exercises; or ii standard clinical care, which includes information on weight loss and exercise. CEP patients with mean 95% CI improvement from baseline in peak VO 2 of 1. 5, 2. 5, 3. 2, 3. 2, 3. 3, and 2. 2 1. 1, 3. 3, and 36 weeks respectively, at 8, 16, 24, and 36 weeks respectively. These changes in CEP patients were much greater than those seen in controls at 16 p. =0. 002, 24 p=0. 031, and 36 weeks p 0. 001.

Source link: https://europepmc.org/article/MED/35853580


FLOWERING REPRESSOR AAA + ATPase 1 is a novel regulator of perennial flowering in Arabis alpina.

Arabis alpina is a polycarpic perennial in which PERTINUAL FLOWERING1 controls flowering and perennial characteristics in a vernalization-dependent manner. We also characterized its position in A. thaliana using CRISPR and A. alpina by introgressing mutant alleles into wild type background, including mutant alleles from wild type families. In the vasculature of young leaf primordia and the flowering shoot apical meristems, AaFRAT1 was detected in young leaf primordia and the rib zone of flowering shoot apical meristems. On the other hand, A. thaliana CRISPR lines displayed weak flowering phenotypes. AaFrat1 plays a role in flowering time control and A. alpina's perennial growth pattern.

Source link: https://europepmc.org/article/MED/35832005


Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis.

We also consider how advances in cryo-EM, computational structure estimation, and mechanisms of related ATPases are improving our knowledge of how Pex1/Pex6 converts ATP hydrolysis into mechanical force. Since mutations in PEX1 and PEX6 cause the majority of known cases of peroxisome biogenesis disorders, such as Zellweger syndrome, the majority of reported cases of peroxisome biogenesis disorders such as Zellweger syndrome, as well as research into Pex1/Pex6 anatomy and function are crucial in understanding peroxisome biogenesis disorders in human health and disease.

Source link: https://europepmc.org/article/MED/35805150

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions