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AAA - DOAJ

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Last Updated: 21 July 2022

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Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis

We also consider how advances in cryo-EM, computational structure estimation, and mechanisms of related ATPases are improving our understanding of how Pex1/Pex6 converts ATP hydrolysis into mechanical force. Understanding peroxisome biogenesis disorders such as Zellweger syndrome, Pex1 and PEX6 mutations are among the majority of known cases of peroxisome biogenesis disorders such as Zellweger syndrome, Pex1 and PEX6 growth and function, according to the majority of recognized cases of peroxisome biogenesis disorders, such as Zellweger syndrome, the majority of common peroxisome biogenesis disorders such as Zellweger syndrome, research into Pex1/Pex6 structure and function are vital for understanding peroxisome biosynthesis of human health and disease.

Source link: https://doi.org/10.3390/cells11132067


Endovascular Repair for a Ruptured AAA due to a Combined Type IIIb and Ia Endoleak

We present a case of a ruptured abdominal aneurysm triggered by a combination of type IIIb and Ia endoleak. The CT scan depicted a type Ia endoleak and a migrated Talent endograft. Simultaneous treatment of combined type IIIb and Ia endoleaks has not been described. Without a doubt, the type IIIb endoleak is the main agent responsible for sac expansion, neck recontouring, proximal migration, and, eventually, type Ia endoleak, which results in significant increase and rupture. In those patients, the placement of an aortic cuff to seal the proximal endoleak/migration and kissing endografts limbs for the fabric tear seems to be a safe option.

Source link: https://doi.org/10.1155/2018/1502328


Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis

Three AAA-ATPases are currently implicated in the reconditioning of the eukaryotic ribosome, a megadalton range ribonucleoprotein complex that is responsible for the translation of mRNAs into proteins. A slew of additional and transiently acting pre-ribosome maturation factors that behave in a synchronized and spatially coordinated manner aid in the correct assembly of the ribosome. After successfully serving their role in the maturation cascade, these AAA-ATPases provide electricity for the effective removal of specific assembly factors from pre-60S particles.

Source link: https://doi.org/10.3390/biom9110715


Unscrambling an egg: protein disaggregation by AAA+ proteins

Abstract In either refolding or degrading aggregation-prone species, a protein quality control system, made up of molecular chaperones and proteases, regulates protein folding status and prevents the aggregation of misfolded proteins. Hsp104/ClpB is a vital player in cell survival in these situations because it has the ability to retrieve proteins from an aggregated state in cooperation with an Hsp70 chaperone system. The ring-forming Hsp104/ClpB chaperone of the AAA+ protein superfamily, which in general aids protein complex assembly and disassembly of protein complexes by ATP-dependent remodelling of protein substrates.

Source link: https://doi.org/10.1186/1475-2859-3-1


Dosimetric Accuracy Comparison between ACUROSE XB, AAA and PBC Dose Calculation Algorithms in EclipseTM TPS Using a Heterogeneous Phantom

In heterogeneous media, respectively, the maximum differences between calculated dose by TPS and measured dose in TEC-DOC 1583 tests were 2. 5%, 8. 6%, and 16. 1%, respectively. Conclusion: Compared to AAA and PBC algorithms, the Acuros XB algorithm has superior accuracy to forecast the dose delivery in heterogeneous tissues, such as lung.

Source link: https://doi.org/10.18502/fbt.v6i4.2209


Elevated levels of IL-6 and IL-9 in the sera of patients with AAA do not correspond to their production by peripheral blood mononuclear cells

Aneurysm is the stable local dilatation of abdominal aorta. Peripheral Blood Mononuclear cells were isolated from 5 men with confirmed diagnosis of AAA and aortic dilation greater than 5. 5 cm, and 5 men with typical/insignificant angiography, CT-Scan, and Ultrasonography findings, according to the authors. Patients' mean serum IL-6 and IL-9 levels were noticeably higher than those who were not. Patients' PBMCs from patients showed lower IL-6 and IL-9 levels in comparison to controls, but there were no significant differences, but not significant. Patients' mean serum IL-10 and IFN-u03b3 levels were marginally higher than controls. Mean serum IL-2 level was not different between the two groups, but its PBMCs' production was much higher than the control group's. Conclusions: Our report found differences in the levels of cytokines from inflammatory, Th1, Th2, and Th17 subtypes in the serum of patients with AAA.

Source link: https://doi.org/10.1016/j.artres.2017.12.007


Structural Elements Regulating AAA+ Protein Quality Control Machines

Although most AAA+ proteins have a ring-shaped shape, AAA+ proteins have created specific structural elements tailored to their specific functions, such as zinc-plated aluminum. We'll look at structural elements present in AAA+ proteins involved in protein quality control in this mini-review, comparing them to the common role of AAA+ proteins involved in DNA translocation. Lastly, we will discuss our latest findings on the inter-relationship of those structural components and design a model showing how ATP binding and hydrolysis might be related to polypeptide translocation in protein quality control systems.

Source link: https://doi.org/10.3389/fmolb.2017.00027


Thidiazuron induced plant regeneration in callus culture of triploid banana (Musa sp.) ‘Gros Michel’, AAA group

A young yellow friable calluses of banana were initiated by the AAA group in vitro firing buds cultured on Murashige and Skoog solid medium supplemented with 2,4-dichlorophenoxyacetic acid and coconut water, according to the manufacturer. After friable calluses were transferred to half-MS liquid media supplemented with 1. 5 mg/l 2,4-D or 1. 5 mg/l 2, 4-D or CW, small spherical, compact calluses were born. In combination with 5% CW or without 2,4-D and CW, small spherical, compact calluses were manufactured. Plants were recovered on MS maturation medium containing 0. 5 mg/l BA and 0. 2 percent activated charcoal.

Source link: https://doaj.org/article/be0fbf90bdeb46d7baf4a3caf2d7444b


AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.

FIGL1 limits CO formation genome-wide, that FIGL1 monitors the diffusion of homologous chromosomes, and that FIGL1 does not interfere with homologous chromosome interactions, according to we, suggesting that FIGL1 counteracts DMC1/RAD51-mediated inter-strand invasion to minimize CO formation. FANCM's crossover frequency rises synergistically when depleting both FIGL1 and the recently identified anti-CO helicase FANCM. In addition, we found that the effect of mutation FANCM on recombination is much smaller in F1 hybrids compared to the phenotype of inbred lines, rather than in bred hybrids, although figl1 mutation also raises crossovers in both cases.

Source link: https://doi.org/10.1371/journal.pgen.1005369

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions