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Abstract Abstract: Molecular-targeted therapy for non-small cell lung cancer, the most common lung cancer, has emerged as a mainstream treatment for both men and women, with non-small cell lung cancer accounting for the majority of cancer deaths. Consequently, chemisensitizers are required to confirm Erl's safety in NSCLC therapy. thermal cycling hyperthermia, a novel thermal therapy that can enhance Erl's effects, was shown to Erl by the study's downstream of EGFR signaling cascades, sensitizing A549 NSCLC cells to Erl.
Source link: https://doi.org/10.1101/2022.05.03.490542
Peimine and Peiminine are isosteroidal alkaloids with various biological functions, including anticancer and anti-inflammatory, but their cellular uptake and pharmacokinetics are uncertain. Peimine and peiminine concentrations in A549 cells were determined in this research by a fast and accurate ultra-performance liquid chromatography-tandem mass spectrometry system. In the A549 cells, the uptake experiment revealed a time-dependent characteristic. The combination group had increased uptake and had a longer Tmax than the single group. Peimine and peiminine's cell lines' cellular uptake profiles and pharmacodynamics of these drugs are investigated in A549 cell lines for the first time.
Source link: https://doi.org/10.1155/2022/2946201
In our previous research, we have found one curcumin analog MHMD could cause apoptosis of lung cancer cells A549 by extrinsic and intrinsic pathways. After MHMD treatment at 48 h, a total of 16584751 clean records from the 21831774 sequence reads were obtained, and 85. 7 percent of them could be mapped on the human test genome. Here, the transcriptomic profile of A549 cells was determined with RNA-seq method.
Source link: https://doi.org/10.14715/cmb/2017.63.9.7
Curcumin derivatives had been paying more attention since their high bioavailability or water solubility, which may have herein replaced the curcumin in future functional applications. The anti-migration activity of ZYX01 in A549 cells was also investigated by wound healing assay and transwell experiments. Current findings had demonstrated that ZYX01 promoted autophagy in A549 cells autophagy through the AMPK/Beclin-1 pathway, shedding light on the future research into the anti-cancer molecular mechanism.
Source link: https://doi.org/10.14715/cmb/2019.65.2.1
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