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Hypochlorous acid is a vital signal molecule in cancer cells. By a HOCl probe named ZBM-H, lung cancer cell growth has been reduced. However, the role and underlying mechanism of GRP78 ATPase in lung cancer cell migration have yet to be established. In A549 cells, ZBM-H time-dependently reduced the protein level of integrin u03b24.
Source link: https://europepmc.org/article/MED/36203272
Therefore, the new paper discusses green synthesis by using oleo-polyol as a surface modifier and synthesis agent for bimetallic magnetic magnesium nanoparticles. The role of hydroxyl functionality of castor oil in the improvement of structural, morphological, magnetic, and particle size properties has also been explored. In vitro, lung cancer cells have been tested to see the effects of calcined temperatures on the anticancer activity of these nanoparticles. The green synthesis of magnesium nanoferrite particles by using natural polyol and their use as anticancer agents against lung cancer cells has not been reported before.
Source link: https://europepmc.org/article/MED/36326716
CHK1 is largely responsible for the study's success in the gemcitabine-resistant lung cancer cell line A549. The results revealed that CHK1 and gemcitabine inhibition in a significant way reduced the two cell lines' proliferation capability significantly. Inhibition of CHK1 resulted in increased production of CDK2/Cyclin A2 and CDK2/Cyclin E1 complexes, and more cells were recruited into the next cell cycle, contributing to S phase arrest and mitochondrial failure. We discovered inhibition of CHK1 as a potential treatment for NSCLC, and we also learned that blocking this kinase would result in decreased gemcitabine resistance.
Source link: https://europepmc.org/article/PPR/PPR566589
Particulate matter with an aerodynamic size u2264 10 u03bcm is a risk factor for lung cancer formation, mainly because some components are incredibly toxic. Through the AhR pathway, we tried to show that PM 10 exposure induces AP-1 family members, cell migration, and other carcinogenic pathways, as well as lung epithelial cells. Methods and results The role of the AhR gene in cells exposed to PM 10 and BaP for 48 h was explored using AhR-targeted interference siRNA. We then found that cell in A549 cells exposed to PM 10 and BaP is modulated by AhR. In addition, the effects induced by PM 10 exposure were similar to those induced by BaP, which highlight the potentially harmful properties of the PM 10 mixture in lung epithelial cells.
Source link: https://europepmc.org/article/MED/36309615
Both men and women, lung cancer has remained the leading cause of morbidity and mortality. The current research was designed to minimize photodynamic therapy dose dependence in vitro and assess the anticancer effects of Dicoma anomala root extracts on A549 lung cancer cells, in order to enhance photodynamic therapeutic outcomes in vitro. PDT IC 50 The most representative extract of D. anomaly was used to establish the 50% inhibitory concentration, which was later used to determine the anticancer effectiveness of D. A in combination with ZnPcS 4 mediated PDT IC 50. In combination therapy groups, Apoptosis is the most commonly used cell death pathway discovered. D. A root extracts in monotherapy and in combination with ZnPcS 4 mediated PDT have been shown to have cytotoxic and antiproliferative properties in vitro experiments. Our findings showed that D. A. may be a promising therapeutic candidate worth investigating in various forms of cancer.
Source link: https://europepmc.org/article/MED/36291155
However, the mechanisms underlying TRAIL's effect on protein expression, signal transduction, and apoptosis induction are uncertain. Hence, we investigated the proteome and phosphoproteome of non-small cell lung cancer cell lung cancer cell line A549 treated with TRAIL. Metal ion binding was significantly affected by TRAIL treatment, according to a Gene ontology functional review. According to the Kyoto Encyclopedia of Genes and Genomes pathway enrichment report, nearly all pathways that involved differentially expressed phosphosites were associated with apoptosis. The findings of this study may provide insight into future research into tumor therapy using TRAIL.
Source link: https://europepmc.org/article/MED/36222260
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