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A431 Cell - Europe PMC

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Last Updated: 10 October 2021

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The Association of Propranolol with 2DG Reduces the Metabolism and the Proliferation of Cutaneous Squamous Cell Carcinoma A431 Cell Line

Since the expression of β-adrenoceptors in the A431 squamous cell carcinoma human cells was explained, we had suggested that cSCC expansion may be managed by using β-AR-blockers. Our results have shown that the addition of 2DG to -Propranolol Hydrochloride therapy can improve its result on A431 cells metabolic process and spreading, suggesting that the combination of -Propranolol Hydrochloride with reduced dose of 2DG might be an encouraging treatment to be topically used as an adjuvant pre-surgical therapy against cSCC, aiming to lower the dimension of the injury prior to the operation, avoiding systemic adverse impacts to the individual.

Source link: https://europepmc.org/article/PPR/PPR401863

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions