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Human 8-oxoxogenine DNA glycosylase is a key enzyme that is responsible for the start of the base excision repair of 7,8-dihydro-8-oxoboxoi. Thanks to positive reactions in the process of DNA exchange linking, which results in negative enthalpy change, as well as partial desolvation of the surface between the DNA and enzyme, which results in positive entropy change, the initial step of DNA substrates binding has been largely dictated by energy, according to thermodynamic investigations. In the second step of the oxoG-substrate binding, discrimination of non-specific G base against a specific oxoG base is present. The final tuning of the enzyme/substrate complex is the final step in the enzyme/substrate complex's catalytically fit condition, with a significant increase in entropy attributed to dehydration of the DNA grooves.
Source link: https://doi.org/10.1371/journal.pone.0098495
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