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4-Hydroxybenzoic acid - Europe PMC

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Last Updated: 16 January 2022

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Enhanced production of γ-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation.

-amino acid 3-amino-4-hydroxybenzoic acid is a precursor to thermostable bioplastics. Under aerobic conditions, a recombinant Corynebacterium glutamicum strain KT01, which contained griH and griI genes derived from Streptomyces griseus, produced 3,4-AHBA with substantial amounts of amino acids as by-products. At a DO of 33% saturated oxygen, metabolic shifts in both the central metabolic pathway and amino acid metabolism were shown in the results of the metabolome study, which revealed metabolic shifts in both the central metabolic pathway and amino acid metabolism. In a glucose-fed-batch culture, the An ldh deletion mutant, which was lacking lactate dehydrogenase, had 3. 7-fold higher specificity of 3,4-AHBA at DO = 0 ppm. Conclusions Our findings revealed changes in the metabolic state in response to DO concentration, as well as insights into oxygen supply during fermentation and the rational design of metabolic pathways for improved production of related amino acids and their derivatives.

Source link: https://europepmc.org/article/MED/34949178


Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals.

The aim of the current research was to explore the involvement of surfactants and polymers in cocrystals' dissolution-supersaturation-precipitation behavior. As a model cocrystal, Tecovirimat-4-hydroxybenzoic cocrystals were chosen. PXRD, DSC, SEM, and FTIR were among the first to engineer and test prototypes of the TEC-HBA cocrystals. The effects of surfactants and polymers on the solubility and dissolution of TEC-HBA cocrystals under sink and non-sink conditions were then investigated. According to the longer T max and higher C max, both the surfactants and polymers had significant dissolution improvement results, and most of the polymers were more efficient than surfactants, according to the longer T max and higher C max. These results show that the dissolution behavior of cocrystals could be improved by the additives' maintained supersaturation effect. Interestingly, we found a linear correlation between the solubility and C max of the dissolution curve for surfactants' dissolution curve, although no such effects were found in polymer solutions.

Source link: https://europepmc.org/article/MED/34834187

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions