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Last Updated: 10 January 2023

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Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

Purpose: Investigation of the acute respiratory distress syndrome in young adults following severe acute respiratory syndrome coronavirus 2 infection has been limited in young adults. Following infection with SARS-CoV-2 in a young adult population, we reviewed the risk factors and effects of ARDs. Methods: A retrospective cohort analysis was conducted between January 1st, 2020 and February 28th, 2021, using patient-level electronic health data from 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR. Through a federated review, we compared young patients with and without ARDS to determine the risk factors associated with ARDS. We've also compared the results between young and elderly patients with ARDS. Following SARS-CoV-2 infection, a large international cohort study of young adults developing ARDS has been conducted, which has resulted in a substantial international cohort study.

Source link: https://doi.org/10.1371/journal.pone.0266985


Metabolic syndrome and its associated factors among epileptic patients at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia; a hospital-based comparative cross-sectional study

Metabolic syndrome is a group of metabolic risk factors that are correlated with an elevated risk of cardiovascular disease and type 2 diabetes. Several studies have revealed that the burden of metabolic disease among epileptic patients is on the rise, leading to MS-associated problems, including cardiovascular disease. Accordingly, we investigated the prevalence and causes of metabolic syndrome in epileptic patients in Dessie Comprehensive Specialized Hospital in compression with respective controls. Using both the National Cholesterol Education Program Adult Treatment Panel III and the International Diabetes Federation definition criteria, the severity of metabolic syndrome was determined. Result: The prevalence of metabolic disease in the epileptic group was 2. 9 percent in National Cholesterol Education Program Adult Treatment Panel III and 14. 7% in International Diabetes Federation criteria among control groups, but not in control groups. Low physical activity, low physical fitness, taking multiple antiepileptic drugs, having a total cholesterol level of u2265 200 mg/dl, and body mass index were all significantly associated with metabolic syndrome among epileptic patients, according to the International Diabetes Federation's guidelines, epileptic participants were strongly correlated with metabolic syndrome. Adult Treatment Panel III guidelines, including multiple antiepileptic drugs, having a total cholesterol level > 200 mg/dl, and body mass index were also highly correlated. Conclusion: By the National Cholesterol Education Program Adult Treatment Panel III, the prevalence of metabolic syndrome among epileptic patients was higher than that of control groups and is statistically significant.

Source link: https://doi.org/10.1371/journal.pone.0279580


Cancer prevention in cancer predisposition syndromes: A protocol for testing the feasibility of building a hereditary cancer research registry and nurse navigator follow up model

Patients with a cancer predisposition syndrome can live longer than others with early detection and risk reduction techniques can save their lives. There is no continuity or coordination of care providing cancer genetics expertise, and there is no way to ensure that patients are referred to the right specialists or risk management services. This paper describes a research protocol to determine the possibility of collecting and analyzing patient risk management results, particularly patients affected by hereditary breast ovarian cancer syndrome and Lynch syndrome. We will determine the priorities and preferences of patients with any inherited cancer mutation for a follow-up navigation system of risk management by doing a qualitative analysis. The findings from the study will support a new research proposal that focuses on the development and analysis of a research registry and a follow-up nurse navigation scheme. Patients will now be able to provide patient preference data to support ongoing and planned studies with cancer mutation carriers.

Source link: https://doi.org/10.1371/journal.pone.0279317


Thoracic outlet syndrome (TROTS) registry: A study protocol for the primary upper extremity deep venous thrombosis section

The pUEDVT has features including venous thoracic outlet syndrome-related upper extremity, deep venous thrombosis, and idiopathic UEDVT. The ThoRacic OuTlet Syndrome registry was established to enhance current research data collection by taking the participation of all relevant pUEDVT treating medical specialists. The TROTS registry's aim is to gather extensive data on all pUEDVT patients using a predefined framework, b give insight into the long-term results using patient reported outcome measures, c develop guidelines on the diagnosis and clinical management of these disorders, and thus provide research for future studies. Methods and evaluation: The TROTS registry was established as an international prospective longitudinal observational registry for patient data collection on pUEDVT patients. Conclusion: The TROTS registry findings will be used to improve understand pUEDVT administration and lay the groundwork for future research and guidelines.

Source link: https://doi.org/10.1371/journal.pone.0279708


Predictors of health self-management behaviour in Kazakh patients with metabolic syndrome: A cross-sectional study in China

However, Muslim minority patients with MS have a difficult time in actively participating in health self-management, and the reasons for their success with MS remain unclear. The aim of this research was to determine the reasons that predict health-management behavior among Kazakh MS patients and provide empirical evidence for the establishment of recommendation or intervention programs for health self-management among Muslim minorities. The complete health self-management behaviour of Kazakh MS patients was 85. 84. 75, and the lack of self-management skills were largely represented in three dimensions: disease self-monitoring, emotion control, and physician-to-one. Conclusion: The health and self-management skills of Kazakh MS patients is poor, according to the author. Physician health care providers in Muslim minority MS patient health self-management should develop culturally specific and effective health promotion services based on the deficiencies and key modifiable influencing factors, thus improving patient health and quality of life.

Source link: https://doi.org/10.1371/journal.pone.0278190


Salivary gland ultrasound is associated with the presence of autoantibodies in patients with Sjögren’s syndrome: A Danish single-centre study

Objectives: To determine whether ultrasound findings of major salivary glands are related to serological markers, autoantibodies, patient- or doctor-reported disease prevalence in a Danish cohort of patients with primary Sju00f6gren's Syndrome. Methods: According to the 2002 American-European Consensus Group classification criteria, 49 patients at Odense University Hospital with ps diagnosed by the 2002 American-European Consensus Group were enrolled. Patients were characterized using the EULAR Sjunef6gren's Syndrome Disease Activity Index and EULAR Sju2019s Syndrome Patient Reported Index, serologic indicators, Schirmer's test, and salivary analysis. Patients with abnormal SGUS were at a higher risk of ANA and anti-Ro52.

Source link: https://doi.org/10.1371/journal.pone.0265057


Eosinophils and basophils in severe fever with thrombocytopenia syndrome patients: Risk factors for predicting the prognosis on admission

BACKGROPHenia syndrome virus, a severe outbreak of thrombocytopenia syndrome virus, is a common tick-borne phlebovirus with a high mortality rate. This research sought to investigate the role of EOS and BAS in predicting the prognosis of patients with SFTS. Methodology: A total of 194 patients with SFTS who were admitted to Yantai City Hospital from November 2019 to November 2021 were included. Findings: In the non-survived group, there were 171 patients in the survived cohort and 23 patients in the non-survived group. Compared to the De-Ritis ratio, the EOS% and BAS% had an area under the curve of predicting poor prognosis among patients with SFTS as a result of poor prognosis. EOS% and BAS% were positively related with a variety of biomarkers of tissue damage and the presence of neurological abnormalities in SFTS patients, and they were strongly associated with various biomarkers of tissue damage and the occurrence of neurological abnormalities. Conclusion: EOS% and BAS% are both useful predictors of poor prognosis in patients with early-stage SFTS. There is no such cure for SFTS, therefore it is crucial to focus on patients infected with SFTSV and determining the underlying risk factors in order to minimize the number of critically ill and fatal cases. For the first time, EOS% and BAS% were used as variables in the present study to predict clinical outcomes in early-stage SFTS patients. Compared to previously reported measures related to medical outcomes, the combination of EOS% and BAS% produced a good predictive result. We also discovered that EOS% and BAS% were both linked to neurological signs and symptoms.

Source link: https://doi.org/10.1371/journal.pntd.0010967


Prevalence and incidence of cyclic vomiting syndrome in Japan: A study using Japanese claims data

Cyclic vomiting syndrome is a gastrointestinal disorder characterized by recurrent episodes of vomiting. Previous studies have provided reliable evidence on the prevalence of CVS among youth in Japan; however, no prevalence nor incidence of CVS is available for adults. Hence, we obtained detailed prevalence and incidence data for CVS and estimated the number of CVS patients in Japan from detailed prevalence and incidence data. Patients with CVS symptoms during the follow-up period were identified with longitudinal data for eligible populations. The Rome IV criteria were used to identify CVS cases in the pediatric and adult populations due to the lack of a single diagnosis code for CVS in 2017. A total of 2,093 patients with CVS was retrieved from 3,506,144 individuals. Our report also contains the first large-population-based estimates of CVS prevalence and incidence in Japan, as well as the first estimates for adult CVS in Japan.

Source link: https://doi.org/10.1371/journal.pone.0279502


Loss of Slc12a2 specifically in pancreatic β-cells drives metabolic syndrome in mice

Type-2 diabetes and cardiovascular disease in people with metabolic syndrome is higher in those with metabolic syndrome, impaired glucose metabolism, hyperinsulinemia, hypertension, and hypertension. In vitro insulin responses to glucose, mice lacking the diuretic-sensitive Na+K+2Clu2212 cotransporter-1 Nkc1 in the pancreatic islet's insulin-secreting u03b2-cells have decreased in vitro insulin responses to glucose. When fed a standard chow diet ad libitum, Nkc1–u03b2KO mice overweightly gain weight and progressive metabolic syndrome. Our results show that primary u03b2-cell defects related to Nkc1-controlled intracellular Clu2212homeostasis and u03b2-cell expansion can result in metabolic syndrome's onset, leading to the discovery of metabolic syndrome, which may have detrimental effects on metabolic homeostasis in vulnerable populations.

Source link: https://doi.org/10.1371/journal.pone.0279560


Education and employment status among adults with Loeys-Dietz syndrome and vascular Ehlers-Danlos syndrome in Norway, a questionnaire based study

Objectives: To identify education attainment and employment status among adults with Loeys-Dietz syndrome and vascular Ehlers-Danlos syndrome, as well as occupational factors, work participation. An article specific survey focused on disease burden and validated methodologies concerning education, burnout, psychological distress, and content with life. Both thirds received disability insurance, and 21 had full-time disability pensions. The full-time employed and students were younger, less sedient, had less sleep problems, and a higher sense of life than those who received disability pensions. Conclusions: It is likely that more adults with these disorders may live longer than others. Health and social care follow-up routines and future studies should include information on career prospects to alert those at risk of low job and to determine modifiable reasons for work participation.

Source link: https://doi.org/10.1371/journal.pone.0279848

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions