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The Middle East respiratory syndrome coronavirus is a highly pathogenic virus that causes severe respiratory disease as well as multi-organ dysfunction, resulting in a 40% mortality rate. The majority of the positive-stranded RNA MERS-CoV genome is converted into two polyproteins, one created by a ribosomal frameshift and two others by a 3C-like protease, as shown by three sites by a papain-like protease and at 11 locations by a 3C-like protease RNA. Since 3CL pro is a key component of viral replication, it is a leading candidate for therapeutic intervention. Three crystal structures of a catalytically inactive version of the MERS-CoV 3CL pro enzyme were determined to accelerate the development of 3CL pro inhibitors.
Source link: https://doi.org/10.1107/s1399004715003521
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