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3 Eye - Europe PMC

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Last Updated: 10 October 2022

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Omega-3 fatty acids in the management of dry eye disease-An updated systematic review and meta-analysis.

Purpose This study was designed to investigate the efficacy of omega-3 fatty acids in comparison to a placebo in the treatment of dry eye disease. Methods A systematic literature review was conducted using randomised controlled trials comparing omega-3 versus placebo in the treatment of dry eye disease in human subjects. Data extraction was carried out using a standardised data extraction technique, and meta-analysis was carried out using a random effects model for continuous data. Scores, Ocular Surface Disease Index scores, tear breakup time estimates, corneal staining, and Schirmer's results were included in the evaluation report. If the I 2 test revealed a value > 60%, statistical uncertainty was considered as high. From baseline to final assessment, the mean change in the OSDI score from baseline to final assessment was shown by a data synthesis. Conclusions This updated systematic review and meta-analysis shows that omega-3 supplementation enhances subjective symptoms in patients with dry eye disease.

Source link: https://europepmc.org/article/MED/36147013


The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3.

Rodent coat color genes have been investigated as a bioresource to investigate developmental and cellular processes. The Downunder rat is a fancy variety with a stripe across its abdomen that runs from the neck to the breech and seems to be a dorsal hooded pattern. The Du gene was linked to rat chromosome 3 and haplotype mapping with congenic rats, limiting the Du locus to a 3. 9-Mb area, according to a 3. 9-Mb region. Zeb2 mRNA levels were significantly lower in Du/+ rats compared to wild-type rats, despite that we found no functional differences within any of Zeb2's exons or intron-exon boundaries. It is known that melanocyte-specific Zeb2 deletion causes mouse congenital hair pigmentation. Our findings show that the Du mutation has pleiotropic effects on hair pigmentation, eye morphology, and growth, which can be used together.

Source link: https://europepmc.org/article/MED/36123037


A Highly Sensitive and Selective Quinazoline-Based Colorimetric Probe for Naked-Eye Detection of Fe 3+ Ions.

By 1 H-NMR, FT-IR, and Mass spectroscopy, a novel quinazoline-based colorimetric sensor that detected Fe 3+ by naked-eye in a buffered MeOH: H 2 O solvent system within a neutral pH range was synthesized and confirmed by 1 H-NMR, 13 C-NMR, and Mass spectroscopy. Probe 1 demonstrated excellent selectivity and sensitivity toward Fe 3+ ions among many other ions, based on the selectivity test. The mole ratio method was used to determine probe 1's sensing behavior to Fe 3+. The effect of pH on the absorption and stability of probe 1 toward Fe 3+ was investigated. A good linear relationship existed under the optimal conditions, ranging from 50 to 110 nM, with a detection limit of 47. 44 nM. The quantitative determination of Fe 3+ in urine samples of high recovery have shown promising results.

Source link: https://europepmc.org/article/MED/36114902

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions