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"The most common DNA repair method used in the gonad is homologous recombination. " The conserved BTR complex performs at several steps during recombination to destroy joint DNA molecules, thereby mediating the non-crossover result and chromosome stability. Topoisomerase 3 enzymes include a variable number of carboxy terminal zinc finger domains, in comparison to catalytic and TOPRIM domains. The ZnF domain collaborates with RMH-2 to maintain the BTR complex's recombination intermediates and avoid heterologous DNA sequence recombination. ".
Source link: https://europepmc.org/article/MED/35639927
"Dengue is an arboviral disease caused by the dengue flavivirus. " Using structure-based virtual screening and molecular dynamics simulations, the aim of this research was to repurpose FDA-approved drugs against dengue virus serotype 3's RDRP domain. With Glide SP and Glide XP, a two-step docking-based screening procedure was applied to DENV3's RDRP domain. Based on the docking score of the inhibitor with the lowest docking rank, the hitlist was evaluated. Polydatin and betiatide remained stably bound to the receptor, and maintained stable interactions with DENV3's RDRP domain. During simulation, the average Prime MM-GBSA energy of polydatin and betiatide was lower than that of 118797902, indicating that their binding affinity to DENV3 RDRP was greater than that of the norm. ".
Source link: https://europepmc.org/article/MED/35642087
"The discovery of two-dimensional magnets has opened a new field of research, exploring both fundamental low-dimensional magnetism and prospective spintronic applications. " Magnetic skyrmions in Fe 3 GeTe 2's 2D ferromagnet Fe 3 GeTe 2 have been found lately, triggering further application possibilities. The combination of the dominant dipolar interaction and highly temperature dependent out-of-plane anisotropy energy terms results in the selective stabilization of all three states at zero field and at a single temperature, according to the findings, but the Dzyaloshinksii-Moriya dialogue must be present to realize the measured N'u00e9el-type domain walls to realize the estimated N'u00e9el-type domain walls.
Source link: https://europepmc.org/article/MED/35641499
"The ferromagnetic phase of Co 3 Sn 2 S 2 is widely considered as a topological Weyl semimetal," Co 3 Sn 2 S 2's ferromagnetic phase, with evidence for Berry curvature monopoles from transport and spectroscopic probes. We show that this crossover is a result of a 2D phase transition in the DW, in which the magnetization texture changes from continuous rotation to unidirectional change. We suspect that the presence of this 2D transition deep within the bulk's ferromagnetic state is a result of a significant quality factor for magnetocrystalline anisotropy peculiar to this region. This work extends the horizon of the traditional binary classification of DWs into Bloch and N'u00el walls, as well as new methods for manipulating domain walls and their role in electron and spin transport. ".
Source link: https://europepmc.org/article/MED/35637177
"Histone lysine methylations are regarded as important in the regulation of gene expression in several eukaryotes. " In biotic and abiotic stress responses, we investigated the roles of tomato histone H3 methyltransferases Set Domain Group 33 and SDG34. Interestingly, single mutants were resistant to drought, while the double mutant showed superior tolerance and plant growth consistent with both independent and additive functions. Mutation tolerance is also a factor that contributes to H3K4 and H3K36 trimethylation decreases in troubled plants, as well as the appearance of negative regulators in troubled plants.
Source link: https://europepmc.org/article/MED/35633111
"LIM domain-binding 3 is a member of the Enigma family of PDZ-LIM proteins. LDB3 is broadly expressed in human and mouse's central and peripheral nervous system. Filamin C and myotilin interactors are also expressed in the spinal motor neuron, nerve, and neuromuscular junction, thus providing the basis for neurogenic disorders associated with mutations in these so-called muscle proteins.
Source link: https://europepmc.org/article/PPR/PPR497225
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