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3 Domain - Europe PMC

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Last Updated: 10 November 2022

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Domain Switching in BaTiO 3 Films Induced by an Ultralow Mechanical Force.

Due to the flexoelectric effect, mechanical force is considered a low-energy consumption method for changing the polarization of ferroelectric films due to the flexoelectric effect. The mechanical switching behaviors of BaTiO 3 / SrRuO 3 epitaxial heterostructure grown on Nb:SrTiO 3 substrate are documented in this paper. The low mechanical threshold is attributed to the small compressive strain, the low oxygen vacancy percentage in BaTiO 3 film, and the SrRuO 3 electrode's high conductivity. In comparison to the electrically written ones, mechanically written domains have several advantages: low charge injection, low energy usage, high density, and improved stability can all be present.

Source link: https://europepmc.org/article/MED/36281808


SH3 Domain-Binding Glumatic Acid-Rich Protein-Like 3 is closely associated with hyperglycemia and poor outcome in Epstein-Barr Virus-negative Gastric Carcinoma

Methods used by SH3BGRL3 in GC from the database of The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus, with various online bioinformatic tools to analyze messenger RNA levels of SH3BGRL3 in GC. To measure SH3BGRL3 expression in GC patients' clinicopathologic characteristics and outcomes, RT-qPCR and tissue microarray-based immunohistochemistry were performed. In the meantime, the relationships between SH3BGRL3 expression and immune infiltrating cells were investigated. SH3BGRL3 showed aberrant expression in tumor tissues when compared to adjacent normal tissues at mRNA levels and protein expression, particularly in EBVnGC. According to a multivariate analysis, elevated SH3BGRL3 expression was a significant risk of EBVnGC patients's overall survival. The DEGs of SH3BGRL3 were mainly enriched in regulating ATP metabolism, ATP synthesis, oxidative phosphorylation, and electron transport chain in GC, according to a Gene functional enrichment study.

Source link: https://europepmc.org/article/PPR/PPR561948


Two closed conformations of CRAF require the 14-3-3 binding motifs and cysteine-rich domain to be intact in live cells

In the cellular signal transduction process, the protein rapidly increased fibrosarcoma is a kinase downstream of the membrane protein RAS. In this research, we used alternating laser excitation to measure cytosolic CRAF in live HeLa cells and then established single-molecule F6rster resonance energy transfer distributions of the structural states. Global fitting with three beta versions was determined of the smFRET manufactures of full-length CRAFs. Our findings revealed that a 14-3-3 dimer bound to two sites on a single CRAF molecule and catalyzed the formation of the autoinhibitory closed conformation.

Source link: https://europepmc.org/article/PPR/PPR562530


The NLR family pyrin domain containing 3 inflammasome in the mechanism of electroacupuncture: Current status and future perspectives.

As keywords and based on the latest randomized controlled trials or clinical trials, we summarize the mechanisms of electroacupuncture targeting NLRP3 inflammasome in the treatment of various diseases, as well as how to optimize the electroacupuncture protocol to obtain thorough mechanisms of NLRP3 inflammasome in electroacupuncture and raise the level of evidence.

Source link: https://europepmc.org/article/MED/36337711


Long noncoding RNA maternally expressed gene 3 improves trophoblast dysfunction and inflammation in preeclampsia through the Wnt/ β -Catenin/nod-like receptor pyrin domain-containing 3 axis.

Specifically, gene 3 is thought to have played a role in preeclampsia by blocking the migration and influx of trophoblasts and encouraging apoptosis. Nonetheless, the precise mechanism that MEG3's specific downstream molecular mechanism is less well understood. Lower expression levels of MEG3 and u03b2 in placental tissues of pregnant women with severe preeclampsia and increased expression of nod-like receptor pyrin domain-containing 3 in placental tissues of women with elevated preeclampsia in chronic pregnancies were found in this research. In the sPE group, elevated serum IL-1u03b2 and TNF-u03b1 were also present. In the H/R group, similar findings were obtained with the sPE group as in the control group. The latest report revealed that MEG3 regulates trophoblast function and inflammation along the Wnt/NLRP3 axis, giving new insight into the origins of preeclampsia.

Source link: https://europepmc.org/article/MED/36310595

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions