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Cells begin to accumulate lipids after adipogenic differentiation after adipogenic differentiation. After adipogenic differentiation, key regulators of adipogenesis are stimulated, and cell cells begin to accumulate lipids. We performed lipidomics and gene expression analysis of undifferentiated and differentiated 3T3-L1 cells to determine specific changes in lipid composition and gene expression during 3T3-L1 cell adipogenesis. Increased expression levels of Pnpla2, Lipe, Acsl1, and Lpl are likely to increase intracellular free fatty acids, which can then be used for the synthesis of other lipids, such as sphingomyelin and ceramide. Enriched intracellular diacylglycerol may also provide more raw materials for the manufacture of phosphatidylinositol, phosphatidylcholine, phosphatidylethanolamine, ether-PE, and ether-PC, whereas high presence of Pla3 may increase the production of lysophophophophophophatidylcholine and lysophosphatidylethanolamine.
Source link: https://europepmc.org/article/MED/35529487
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