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"Abstract Background Cancer remains one of the leading causes of death worldwide. " A docetaxel formulation solubilized in a tween 80 percent and 13% ethanol solution is available at Main body Taxotere. Poor mixing results in gel formation are common, but adding the drug mix to an infusion may result in micelle formation. To ease administration of the drug, pharmacists have also attempted to produce an oral docetaxel formulation. Attempts have also been made to produce other dosage forms, including transdermal formulations and implants, that can be directed at cancer cells while minimizing systemic side effects. Conclusions With several docetaxel derivatives currently in clinical trials, the development of novel docetaxel products for various chemotherapeutic needs seems promising. New anticancer formulations may be produced in the future if investigating other drug manufacturing techniques, such as the use of 2D LDH.
Source link: https://doi.org/10.1186/s42269-022-00854-5
"Nowadays, various tissue engineering techniques have been applied to repair bone and osteochondral fractures, as well as stem cell regeneration. " The first layer was HA/u03b3-PGA, and the second and fourth layers were Col/u03b3-PGA. Both scaffold and membrane samples were tested for biocompatibility property and degradation activity. Cell attachment, proliferation, and differentiation were measured in-vitro by Rat bone marrow stem cells and human adipose-derived stem cells, which were cultured on the samples and tested in-vitro to determine cell attachment, proliferation, and differentiation. In the rat and nude mouse models, In-vivo experiments were conducted. In both in-vitro and animal tests, the demonstrated scaffold provides superior microdegradation and biocompatible characteristics, and the Col-HA scaffold enhances bone osteochondrogenesis's mechanical properties. Conclusions The composite will be a useful biomaterial tool for bone and osteochondral regeneration," the author states.
Source link: https://doi.org/10.1186/s40824-022-00265-7
"Once the automated detector system can produce whole-body images in a short time, it may experience diagnostic difficulties in certain regions due to the use of high-energy X-rays during whole-spine and long-length examinations. " The most accurate results were obtained when the composite extra filter, which was based on a 14 mm thick Al + 1 mm thick Cu material, was used under all X-ray inspection conditions. In the X-ray photos obtained with the composite additional filter in comparison to the images obtained with no filter, we reported that an SNR increase of up to 46%, CNR increase of 37 percent, and radiation dose reduction of 90% could be achieved. The additional filter made with a 3D printer was effective in improving image quality and lowering the radiation dose for X-ray images produced with a long-length detector," according to the researchers.
Source link: https://doi.org/10.3390/s22114299
"The aforementioned PET material could be 3D printed to produce the required parts for performance analysis before mass production by injection molding. " The addition of talcum powder enhanced filament's thermal stability, resulting in a collision between the fillers and polymer matrix, as well as Thermogravimetric Analyzer's. The expanded molecular weight of the extruded PET filament was then compared to the yield strengths and Young's moduli to find the effects of the reduced molecular weight of the extruded PET filament's increased molecular weight. The talcum powder effectively enhanced the PET's viscosity during the extrusion process for the filament and then improved the PET's crystallinity, resulting in a significant rise Young's modulus. The printed PET specimen displayed a high yield strength of 25 MPa and ductile characteristics with strain-at-break values of 30 percent, indicating potential uses in food-contact tableware and bio-implants. ".
Source link: https://doi.org/10.3390/polym14112276
"3D printing is an emerging and effective way to produce three-dimensional structures for tissue engineering applications. " Sing electron microscopy and infrared spectroscopy revealed the morphological microstructure of the hydrogel scaffolds made of Alg, 40% of MCC inks, and Fmoc-FFY peptide, establishing the morphological morphology of the peptide in a u03b2-sheet conformation. Lastly, the scaffolds' cytocompatibility was tested in contact with the MG63 osteosarcoma cells, revealing the absence of cytotoxic components that could jeopardize their viability. Interestingly, cell growth in MG63 cells that contained the peptide was delayed in the scaffolds carrying the protein, but cells were more likely to promote adhesive interactions with the protein than in the other cells, highlighting the benefits of the peptide in increasing biological stability to alginate-based biomaterials. ".
Source link: https://doi.org/10.3390/polym14112229
"Intrasaccular flow disrupter systems have provided new ways to treat intracranial aneurysms, but choosing the right size of ISFD can be difficult. We outline the first use of 3D printing to aid in the choice of ISFD, and we provide an illustrated case. On the 3D model under fluoroscopy, We tested the usage of various types of intrasaccular flow disruptors. Intracranial aneurysm treatment using ISFD may reveal intriguing details regarding the treatment of intracranial aneurysms. ".
Source link: https://doi.org/10.3390/jcm11112950
"The manufacturing of functional foods by 3D printing is considered here as one of the most feasible methods to provide closer food personalization to the population. " This work will investigate the introduction of rosehip as a useful ingredient in a gluten-free dough. The bread made with rosehips had more orange hues in dough and crumbs than that of crumbs. Rosehip makes the product more stable to breakage, which may be due to the rosehip's wool content.
Source link: https://doi.org/10.3390/foods11111555
"While 3D printing technology has been improving for many years, it is also facing a huge challenge to produce 3D metal structures with high-resolution. " The proposed method was found to greatly raise the capability of 3D printing by combining the advantages of 3D printing in structure design with those of surface modification assistance by catechol groups, and it could lead to the demise of 3D printing in electronics, acoustic absorption, catalyst supports, and other fields.
Source link: https://doi.org/10.1016/j.jmrt.2022.05.009
A method for silicon oxide ceramic sculpture based on 3D printing technology is suggested in order to solve the art decoration design of silicon oxide ceramic sculpture. " Firstly, the photosensitive resin premix density before curing was determined by the pycnometer method; the photosensitive resin was coated on tinplate and then transferred to a self-made UV curing box for curing. "Eventually, the viscosity of ceramic slurry was determined by mixing S2 photosensitive resin formula with ceramic powder with varying nano silica content. ".
Source link: https://doi.org/10.1155/2022/9728402
"Three-dimensional engineered cardiovascular tissues have shown a great promise to repair damaged organs. " Specifically, tissue engineering vascular grafts have the ability to replace biological and synthetic grafts. We intended to produce an in-vitro patient-specific patch based on a hybrid 3D print and vascular smooth muscle cells differentiation. We rated the most hemodynamically effective aortic patch surgical repair based on the medical records of a 2 months-old girl with aortic arch hypoplasia and computational modeling. "endothelin-1" was a characteristic functional vasoactive response to endothelin-1. ".
Source link: https://doi.org/10.1016/j.mtbio.2022.100252
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