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3d Glass - Europe PMC

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Last Updated: 12 November 2022

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Antibacterial effect of 3D printed mesoporous bioactive glass scaffolds doped with metallic silver nanoparticles.

The development of novel biomaterials for bone tissue regeneration with high bioactivity and antibacterial characteristics is being closely investigated. We have synthesized nanocomposites grown by mesoporous bioactive glasses in the ternary SiO 2, CaO, and P 2 O 5 system, which were homogenously embedded in MBG matrices. By high temperatures at the last MBG synthesis step, silver species were spontaneously reduced to metallic AgNPs by directly synthesized and silver species were spontaneously reduced to metallic AgNPs. Ag/MBG nanocomposites' biological properties were determined by MC3T3-E1 preosteoblastic cells culture tests and bacterial assays. The MC3T3-E1 cells morphology was not affected, indicating that preosteoblastic proliferation was not reduced when the presence of silver increased. AgNPs were indispensable for antibacterial growth in vitro co-culture of MC3T3-E1 cells and S. aureus bacteria, according to researchers, and AgNPs had only marginally affected cell proliferation parameters. Therefore, 3D printed scaffolds with hierarchical pore structure and high antimicrobial capacity have potential uses in bone tissue regeneration. SIGNIFICANCE'S FEED – a study of bone tissue engineering that includes three key scientific aspects: materials with high bioactivity to repair and regenerate bone tissue that contain antibacterial substances to minimize the infection risk in the form of three-dimensional scaffolds with hierarchical porosity. The dual scaffolds are biocompatible and contain active doses of silver capable of fighting bone infections, which are one of the most common problems related to surgical treatment of bone disease and fractures.

Source link: https://europepmc.org/article/MED/36332875


Failure Prediction in 3D Printed Kevlar/Glass Fiber-Reinforced Nylon Structures with a Hole and Different Fiber Orientations.

This report investigated the mechanical results of 3D-printed, fiber-reinforced composites with a rectangular shape and a hole at one end. Because of their wide range of uses, Nyon-6 was chosen as a polymer matrix, glass or Kevlar fibers were chosen as continuous fibers. In 3D-printed specimens with various fiber orientations, a numerical model was created to predict failure modes and damage in 3D-printed specimens with different fiber orientations. For the orientation angles of 0u00b0, 22. 5u00b0, 45u00b0, 67. 5u00b0, and 90u00b0, respectively, the maximum strain was 1. 7 MPa, 3. 2 MPa, 2. 2 MPa, 1. 0 MPa, 1. 0 MPa, 1. 1 MPa, 1. 0 MPa, and 1. 4 MPa. Overall, Kevlar-based composites demonstrated mechanical properties superior to those of glass-based composites. The effect of the fiber orientation was also different between the two methods. The simulation results indicated that failure propagation would begin in the areas near the hole.

Source link: https://europepmc.org/article/MED/36298040


Thermo-Mechanical Reliability Study of Through Glass Vias in 3D Interconnection.

Due to its superior electrical properties, exceptional mechanical stability, and lower cost, a three-dimensional interconnection system based on glass through vias has been used to integrate passive electronics, and optoelectronic equipment. Nevertheless, the device's performance and reliability will be affected by the thermal stress caused by the mismatch of the coefficient of thermal expansion among multi-material structures and the complex structure of TGVs. Thermal stress evolution in various geometric and material properties, as well as the development of a controlled method for filling polymers in TGV interconnected structures is the subject of this paper. In addition, a TGV interconnected structure model with a polymer buffer layer is used to solve the crack problem that appears at the edge of RDL. Based on the above study, an improved manufacturing process flow for the TGV interconnected system was developed and demonstrated as feasible to solve the RDL crack issue.

Source link: https://europepmc.org/article/MED/36296152


Mastoid obliteration and external auditory canal reconstruction using 3D printed bioactive glass S53P4 /polycaprolactone scaffold loaded with bone morphogenetic protein-2: A simulation clinical study in rabbits.

"Canal Wall Down Mastoidectomy" is a fictionalization of "Canal Wall Down Mastoidectomy" in New Zealand rabbits simulating "Canal Wall Down Mastoidectomy" is printed on 3D reconstruction results. Using the CCK8 assay, the cytotoxicity of the S53P4/PCL scaffolds was determined, and the in vitro antibacterial activity of the S53P4/PCL scaffolds was determined by using the inhibition circle technique. In vitro experiments showed that the S53P4/PCL scaffold was non-cytotoxic and had higher antibacterial activity than the same amount of S53P4 powder. In vivo experiments showed that the S53P4/PCL scaffold had good biocompatibility and osteogenic activity, could safely repair bone fractures and reconstruct animal model's normal morphology. Conclusions The 3D printed S53P4/PCL scaffold has a great potential for medical mastoid elimination and external auditory canal reconstruction.

Source link: https://europepmc.org/article/MED/36313396


3D-printed mesoporous bioactive glass/GelMA biomimetic scaffolds for osteogenic/cementogenic differentiation of periodontal ligament cells.

Three-dimensionally printed gelatin methacryloyl scaffold scaffolds have emerged as a promising treatment for periodontal tissue regeneration due to the tunable physical properties and exact control of the scaffold microarchitecture. However, the optimization of the printing biomaterial aids in the formulation and the relationship between the printed scaffold's composition and their extensible properties remains unclear. Our findings showed that the incorporation of mesoporous bioactive glass nanoparticles significantly improved shape fidelity, surface roughness, and bioactivity of 3D-printed macroporous GelMA scaffolds, resulting in enhanced cell adhesion and promoterotic differentiation in human periodontal ligament cells. Our results showed the great promise of the newly produced biomaterial inks and biomimetic BG/GelMA scaffolds for use in periodontal tissue regeneration, as well as critical insights into the role of cell-scaffold interactions in supporting functional periodontal tissue regeneration.

Source link: https://europepmc.org/article/MED/36329698

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions