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3d Cell Culture - Astrophysics Data System

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Last Updated: 10 April 2022

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Numerical and experimental simulation of a dynamic-rotational 3D cell culture for stratified living tissue models

Cell culture reactors, perfusion bioreactors, and microfluidic devices are all commonly used in tissue engineering applications for increasing cell culture viability in 3D constructs. To mimic native tissue's dynamics, perfusion bioreactors, and microfluidic devices are widely used in tissue engineering applications for increasing cell culture viability in the heart of 3D constructs. Cell or tissue exposure to constant and homogeneous compound concentrations over a predefined testing period is the most important in vitro screening techniques for compound efficacy and toxicity determination. For a reliable hold over gradient tissue culture conditions, we here offer a compartmentalized rotational 3D cell culture platform. Closed lanes of constructs are patterned by controlled flow dynamics to enable tissue stratification by using the CR bioreactor. Before the testing of a blood-brain-barrier model showed the effect of a heterotypic culture under mimetic dynamic environments, a proof-of-concept, experiments and accompanying simulation of cell inoculation and growth in 3D scaffold and hydrogel were carried out as a proof-of-concept, a demonstration of molecular permeability was conducted.

Source link: https://ui.adsabs.harvard.edu/abs/2022BioFa..14b5022C/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions