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3d - Europe PMC

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Last Updated: 10 May 2022

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3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs.

Implantable drug delivery systems provide an alternative to long-term disease therapy. Using robocasting 3D-printing and a pre-formed rate control membrane, the present goal of the project was to produce implantable devices containing the model hydrophobic drug olanzapine. OLZ was chosen as a model molecule due to its hydrophobic properties, as well as because it is a good example of a molecule used to treat a persistent condition schizophrenia. OLZ was mixed in the implants with 50 and 80% of OLZ. After the printing process, crystals of OLZ were embedded in the implant. Implants containing 50% and 80% of OLZ's were capable of providing drug delivery for up to 190 days, according to In vitro release studies. Total drug supply was ca. After 190 days, ca. total drug manufacture was ca. Because this polymer acts as a co-solvent of the drug, a faster release is possible in implants containing 50% of OLZ.

Source link: https://europepmc.org/article/MED/35363100


Long-term in vivo survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content.

According to a Proteomic review, 6,067 proteins were discovered, including pericyte markers, adipokines, ASC mystery proteins, proangiogenic proteins, and proteins involved in adipocyte differentiation and developmental morphologic signalling, as well as proteins that had not previously reported in human subcutaneous fat. In addition, we found human blood vessels after 30 and 150 days in vivo, indicating capillary angiogenesis. These results revealed that LAT has a favourable proteomic signature, includes ASCs, EPCs, and blood vessels that survive 3D bioprinting, and can potentially promote angiogenesis and successful autologous fat grafting in soft-tissue reconstruction.

Source link: https://europepmc.org/article/MED/34957918


Analysis on the printability and rheological characteristics of bigel inks: Potential in 3D food printing

Bigels have special characteristics that make them ideal for 3D printing applications. In this research, the 3D printability, rheological characteristics, and microstructure of bigel inks containing 20%, 30%, 50%, 70%, and 80% fractions were investigated. As the oleogel fraction increased, the oleogel value in 3D printing increased, but the n value decreased, indicating that the viscosity and shearing thinning properties increased. In addition, confocal laser scanning microscopy showed in BG1 to BG4, oleogel and hydrogel particles aggregated to different degrees after extrusion, but BG5 remained unchanged. Results showed that as the oleogel fraction increased, the recovery time decreased in bigel inks, and that BG5 could recover within 2 s after extruding. These bigel inks introduce a process for producing high-oil materials that can be used in 3D food printing.

Source link: https://europepmc.org/article/MED/IND607716119


Role of dietary fiber and flaxseed oil in altering the physicochemical properties and 3D printability of cod protein composite gel

Personalized food is created for customers with specific needs using 3D printing technology. Consequently, the new study examined the rheological properties of the cod protein composite gel made on various combinations of inulin/soybean dietary fiber and flaxseed oil content. The results showed the CPCG's suitability for 3D printing with ratios of IN:SDF and 5:5 as well as 10% of flaxseed oil, wherein the gel was extremely thixotropic, making it suitable for use as food ink.

Source link: https://europepmc.org/article/MED/IND607707693


3D food printing curing technology based on gellan gum

Corn starch was used as the printing substrate to create a gel that solidifies during printing. The slurry of gellan gum had good extrusion and printing performance, according to Rheological experiments, printing quality evaluations, and low-field nuclear magnetic fields. Gellan gum, according to temperature sweep rheology reports, influenced the curing process by influencing the curing temperature and curing speed of the slurry. Gellan gum improved the product's hardness and destroyed the network by self-cooling cross-linking and inhibiting starch gelatinization, which improved product adhesion and destroyed network structure.

Source link: https://europepmc.org/article/MED/IND607707692


3D printing of cell-laden visible light curable glycol chitosan bioink for bone tissue engineering

As an alternative, we selected water-soluble methacrylated glycol chitosan, and produced a MeGC-63 cell-laden bioink for 3D printing using a visible light curing method. The results show that MeGC-70 bioinks and 3D printed scaffolds can be used as patient-specific scaffolds for bone regeneration purposes.

Source link: https://europepmc.org/article/MED/IND607700484


Novel 3D porous aerogels engineered at nano scale from cellulose nano fibers and curcumin: An effective treatment for chronic wounds

Traditional cotton gauze made from cellulose has several limitations in wound healing. Due to their biocompatibility and biodegradability, Cellulose nanofibers synthesized from plant waste are promising environmentally friendly nanomaterials. Cellulose nanofibers synthesized from plant waste are promising ecofriendly nanomaterials. Specifically, the 3D porous nano bio aerogel with curcumin helped with the migration of fibroblast cells and was high antimicrobial activity against pathogenic microorganisms. From the findings, we can safely say that this 3D porous aerogel can be used to treat chronic wounds.

Source link: https://europepmc.org/article/MED/IND607700491


The adsorption characteristics of 2D fibril and 3D hydrogel aggregates at the O/W interface combining molecular dynamics simulation

The -helix content and surface hydrophobicity in 2D fibril aggregates were significantly higher than those in 3D hydrogel aggregates, but the -sheet result was not consistent, due to different hydrophobic amino acid sequences. The peak amplitude and crystallinity of interfacial proteins in hydrogel aggregation mode was higher than those in fibril aggregation mode, and crystallization of crystal structure can influence interfacial microstructure. At pH 3. 0 and 3D multilayer network structure are developed at pH 9. 0, the interfacial protein membrane is mainly made of fibrous rod-like aggregates, of which a 2D fibrous network structure is formed. The ability of 3D hydrogel aggregates to reduce interfacial tension is greater, due to the differences in spatial conformation, crystal structure, and adsorption micro-structure exacerbated by emulsification and adsorption.

Source link: https://europepmc.org/article/MED/IND607671384


3D food printing: Controlling characteristics and improving technological effect during food processing

The food industry uses 3D printing technology for a variety of tasks. Current research has primarily focused on improving printing quality and expanding the range of printing options, while 3D printing techniques for monitoring processing characteristics and improving technological aspects have yet to be investigated.

Source link: https://europepmc.org/article/MED/IND607701703


Effects of incubation temperature on the mechanical and structure performance of beeswax-carrageenan-xanthan hybrid gelator system in 3D printing

The influence of incubation temperature on the print quality, rheological stability, and microstructure of beeswax-carrageenan hybrid gelator inks was investigated. The crystal structure of beeswax changed from amorphous to spherulites as the incubation temperature increased from 25 to 35 °C. The beeswax particles in hybrid gelator inks were evenly dispersed and tend to aggregate, resulting in even dispersed. The inks' 0 and n increased from 23. 64 to 33. 68 Pa and 0. 20 to 0. 26, respectively, indicating that the inks had poor mechanical strength and were not conducive to molding. As the incubation temperature reached 55 °C, a large number of needle-shaped crystals appeared in the beeswax, and solid fat content increased from 29. 98 to 30. 6 percent. With good shape retention, the hollow cube model was produced. This paper provides a step by design and application of a novel hybrid gelator system in 3D printing.

Source link: https://europepmc.org/article/MED/IND607660145

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions