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Rippling muscle disease is a condition in which the muscles are remarkably sensitive to movement or pressure. Stretching the muscles in most people with this condition results in noticeable ripples throughout the muscle, lasting 5 to 20 seconds. Some muscle tissue may have overgrowth of some muscles, especially in the calf. The age of onset of rippling muscle disease varies widely, but it is usually present in late childhood or early adolescence. Rippling muscles can also be a symptom of other muscle disorders such as leg-girdle muscular dystrophy.
Distal myopathy is one of the many disorders associated with decreased strength and absence of function in the muscles farthest from the body's center, including those of the hands and feet. People with CAV3-related distal myopathy experience wasting and exhaustion of the small muscles in the hands and feet that are normal in adulthood. The calf muscles can also grow in CAV3-related distal myopathy.
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