* If you want to update the article please login/register
Using office BP measurements, the GLP-1 receptor agonists have been shown to reduce blood pressure in clinical trials. However, the effect of GLP-1 agonist liraglutide on 24-hour ambulatory blood pressure and the nocturnal BP decline in large trials has not been adequately investigated. We conducted a random controlled trial comparing the effects of liraglutide to placebo to better describe the effect of GLP-1 agonists on 24-hour ambulatory BP in people with T2DM. In conclusion, our research indicated that treatment with liraglutide for over 8 weeks was ineffective in addressing the abnormal increase in nocturnal BP seen in patients with T2DM. The ABPM also reported the expected side effect of the rise in heart rate seen in other liraglutide trials. All patients with elevated DBP were found to have abnormal RHI.
Source link: https://doi.org/10.2337/db18-16-lb
Abstract Background Ambulatory blood pressure monitoring using cuff-based systems is used for diagnosis and treatment of hypertension. Purpose The aim of the present study was to determine the sensitivity of a new technique of 24H ABPM using a photoplethysmography-based, wearable device as compared to the common cuff-based ABPM unit. Characteristic curve analysis was used to determine whether the Wrist-monitor could detect abnormal BP values. Findings The survey included 28 people from a mean age of 41. 5 to 16. 2 years, with 28 people from 28 nations mean age 41. 5 to 16. 2 years. Both diastolic blood pressure and systolic blood pressure were estimated in a 24H bias of 1. 1 mmHg for both diastolic blood pressure and systolic blood pressure, according to Bland-Altman's report, which resulted in a 1. 1 mmHg difference in 24H. Mean daytime bias for DBP and SBP was 1. 9 mmHg for DBP and SBP, according to DBP and SBP, although nighttime bias was less pronounced. Both SBP and DBP measured squared output curve analysis of all BP readings resulted in a mean area under the curve for 24H of 0. 965 for both SBP and DBP. Acknowledgement of funding sources: Private company.
Source link: https://doi.org/10.1093/eurheartj/ehab724.2343
Abstract Introduction Ambulatory blood pressure monitoring is increasingly used in clinical research for hypertension's formal diagnosis, and it has been particularly relevant in situations of suspected white-coat effects, masked, or nocturnal hypertension. However, the use of cuffs for ABPM can be painful and cause discomfort, particularly at night, where it can even lead to arousal from sleep and contribute to non-representative nighttime blood pressure values. Purpose: Investigate The aim of this study was to investigate the possibility of using a cuffless watch-like photoplethysmographic sensor for 24-hour ABPM by comparing the PPG-based BP estimates with traditional cuff-derived ABPM values. Methods Our study was approved by the local ethics commission and carried out in 70 participants in a cuff-based ABPM study. Pulstolic and diastolic BP values were estimated by pulse wave analysis of the measured PPG signals. The concordance rate was determined as the percentage of dipping values indicating a concordant trend between both methods. PPG's data quality in four new participants was insufficient to provide adequate BP estimates, owing to poor sensor tightening. In the remaining 62 participants, we discovered differences between the daytime PPG-based and cuff-based BP estimates of 0. 9. 3. 6 mmHg for SBP and DBP respectively. According to a dipping difference of 0. 8 % and 0. 8 percent in SBP and DBP, respectively, there were 0. 1 million mmHg and 0. 5 mmHg. Both SBP and DBP had a 97% CR on dipping, which was 97%. Although our paper was intended as a method-comparison feasibility study, these findings encourage that cuffless ABPM may soon be a clinical possibility.
Source link: https://doi.org/10.1093/eurheartj/ehab724.2348
Abstract Background Hypertension rises overall cardiovascular risk in patients with type 2 diabetes mellitus, contributing to a significant increase in diabetic patients, although control rates of hypertension remain suboptimal. A few randomized controlled trials investigated the effects of GLP-1RAs on ambulatory blood pressure. Ambulatory blood pressure monitoring provides a more accurate way to predict long-term cardiovascular events than office blood pressure. A nonsignificant decrease in 24-h systolic blood pressure and 24-h diastolic blood pressure in comparison to placebo or active control resulted in a nonsignificant decrease in 24-h diastolic blood pressure and 24-h diastolic blood pressure. In patients with T2DM, Antidiabetic treatment with GLP-1RAs does not influence whether systolic or diastolic ABP is present in patients with T2DM.
Source link: https://doi.org/10.1093/eurheartj/ehab724.2950
* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions