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24-Hour Ambulatory Blood Pressure - ClinicalTrials.gov

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Last Updated: 28 April 2022

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24-Hour Ambulatory Blood Pressure Monitoring Study in Hypogonadal Men Receiving Testosterone Replacement Therapy

When applied topically, AndroGel 1. 62% has shown its ability to raise total testosterone levels in the blood by absorption of testosterone through the skin. This report will examine the effects of AndroGel 1. 62% on systolic blood pressure in hypogonadal men using testosterone replacement therapy. This is an open-label investigation, which means that both the study doctor and study participants will know what drug and what dosage are being used. Adult male hypogonadism patients with hypogonadism will be registered and receive AndroGel 1. 6 percent. About 75% of the intended subjects in the PP population have completed the end of treatment visit, a blinded sample size re-estimation will be carried out. For approximately 16 weeks, participants will be given daily topical gel doses of AndroGel 1. 62%. During the course of the investigation, patients will attend 8 research visits, either hospital or clinic, and receive two study phone calls.

Source link: https://clinicaltrials.gov/ct2/show/NCT04274894


Dietary Management and Aerobic Exercise on 24-hour Ambulatory Blood Pressure in Subjects With Prehypertension: Randomized, Single-blinded Clinical Trial

Although most guidelines referred to arterial hypertension in office blood pressure 140/90 mmHg, epidemiological and observational studies revealed that cardiovascular risk progressively increased as blood pressure rises from 115/75 mmHg, suggesting that hypertension is likely to progress to hypertension. In patients with prehypertension who have no randomized, controlled clinical study, a combination of Aerobic exercise and DASH diet has also been suggested.

Source link: https://clinicaltrials.gov/ct2/show/NCT05274971


Chronic Effects of Effective Oral Cannabidiol Delivery on 24-hour Ambulatory Blood Pressure and Vascular Outcomes in Treated and Untreated Hypertension: A Randomized, Placebo-controlled and Crossover Study

DehydraTECH, a Lexaria Bioscience Corp. manufactured a novel formulation processing system that has been shown to improve the results of lipophilic beneficial compounds in oral ingestible goods by increasing the incidence and extent of intestinal biosorption and systemic uptake. Patrician et al. , 2019. For example, DehydraTECH technology has been tested in an oral CBD formulation and found to result in elevated and more rapid levels of delivery, which were reflected in lower blood pressure in young healthy humans, resulting in lower blood pressure in comparison to positive controls with identical CBD concentrations. Screening of visit 1 On the first visit to the initial visit, potential visitors will read through the information and consent form, ask any concerns, and give written informed consent. In the 24 h leading up to your first laboratory visit, all subjects will be asked to keep a food and physical activity diary and to replicate food intake and physical fitness as often as possible. Whether you're looking for a unique way to the lab, visit 2, 3, 3 & 4 - Experimental Trials The second visit to the laboratory will be delayed for at least 24 hours after the first visit to the laboratory and will require participants to remain in the laboratory for at least 2 hours. Oral DehydraTECHTM CBD or placebo control will be available in the following doses approx. The maximum dose approx. will be 450 mg for the last daily dose. In the latest Phase 1 trial by Watkins and colleagues that reported peak serum alanine aminotransferase values were above average in 74% of the 16 participants and exceeded international guidelines for drug-induced liver injury in 51% of these participants Watkins et al. , 2021. The clinical shortage of acute dosing 300 mg DehydraTECH2. 0 CBD has been found; and previous reports have shown much higher acute dosing without a mention of related AEs Sultan et al. , 2020 The 24-hour food log will be reviewed and a copy will be sent to patients who will be asked to repeat the diet 24 hours before the following visit as closely as possible. Following the initial blood draw and questionnaires, participants will then be tested with the 24-hour ambulatory blood pressure monitor ABPM; TM-2430, which will be used to analyze continuous blood pressure measurements away from the laboratory, will be used to analyze continuous blood pressure monitoring. At the University of San Francisco, CA, USA, subjects will also be required to wear a Fitbit activity and sleep monitor Fitbit Inc, San Francisco, CA. USA. The findings of the investigators' previous acute trial that used similar active intervention and outcomes are used in preliminary estimates. Preliminary estimates of the effect sizes for reduced 24-hr ambulatory blood pressure following DehydraTECH2. 0 are based on the findings of the investigators' latest preliminary research that used similar active intervention and outcomes. CBD delivery's new methods have major implications on more specific CBD use in health and disease states.

Source link: https://clinicaltrials.gov/ct2/show/NCT05346562


An Open-Label, Randomized, Parallel-Group, Three Treatment Arm, Multicenter Study on Hypogonadal Males to Evaluate the Effect on 24-Hour Ambulatory Blood Pressure After 16-Week Continuous Administration With Marketed Testosterone Products

Testosterone is the most common androgen produced by the male testes. Testim® and Fortesta® are topical gels that can be used daily to raise the blood testosterone levels in the blood by skin absorption. After 16 weeks of therapy using 24-hour Ambulatory blood pressure, shifts in BP levels were found, and this research is designed to determine the effect on blood pressure of approved testosterone products.

Source link: https://clinicaltrials.gov/ct2/show/NCT04456296

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions