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22q11 Deletion Syndrome - Springer Nature

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Last Updated: 16 April 2022

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Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs

BACKGROUNDING BACKGROUND ISLAND XIA infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency and in a subgroup of infants with 22q11 deletion syndrome reveals infants with profound T lymphopenia. The 22q11Low group had lower numbers of nave T-helper cells, na've T-regulatory cells, nave cytotoxic T cells, nave cytotoxic T cells, and gradually reduced TRECs compared to healthy controls as compared to healthy controls. Compared to nave cytotoxic T cells, shorter RTL, and a trend toward higher clonality were found for nave T-helper cells in nave T-helper cells, according to skewed V-gene use for nave T-helper cells, despite a trend towards increased clonality in the nave T-helper cells. In both the 22q11Low and 22q11Normal groups, there were greater numbers of nave B cells and lower amounts of memory B cells, as well as switched memory B cells.

Source link: https://doi.org/10.1007/s10875-021-01201-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions