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However, brain function is largely limited by underlying white matter pathways and the study of function-structure dependence, which, in contrast to conventional unimodal analysis, allows for a biologically relevant assessment of neural functions. Firstly, we used a graph signal processing device to aggregate brain activity and structural connectivity measurements to produce regional structural decoupling indices. We use SDI to determine the differences in functional structure dependencies between the two groups. Participants of 22q11DS also had to investigate how FSD changes are related to the severity of positive psychotic symptoms in participants with 22q11DS. Functional results in participants with 22q11DS, as well as more in deletion carriers with more prominent positive psychotic signs, were more dependent on the underlying gyrus and subtical dopaminergic regions than in cingulate cortex than in placebo patients with more pronounced positive psychotic symptoms.
Source link: https://europepmc.org/article/MED/35717884
The 22q11 deletion syndrome is the most common microdeletion disorder in humans, and it increases the risk of developing psychiatric disorders. Six genes for mitochondrial proteins are highly expressed in mouse models and stimulated right after birth, implying that mitochondrial functions are strictly related to synapse formation and maintenance of a good synaptic signalling.
Source link: https://europepmc.org/article/MED/35457231
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