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21 Down Syndrome Trisomy - Europe PMC

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Last Updated: 05 May 2022

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COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated.

Individuals with Down syndrome are one of the population most vulnerable to severe COVID-19. Immunization uptake can be enhanced by better knowing the effectiveness and risks of COVID-19 vaccinations for people with DS. The T21RS COVID-19 Initiative initiated an international search to gather data on the safety and efficacy of COVID-19 vaccines for people with DS. When it comes to completely vaccinated people with DS, it has been shown to be safe for individuals with DS and efficient in terms of minimal breakthrough infections and milder disease outbreaks among fully vaccinated individuals with DS.

Source link: https://europepmc.org/article/MED/35455279


Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21.

Children with Down syndrome are at a high risk of acute myeloid leukemia. Unique mutations in GATA1, a key hematopoietic transcription factor, were discovered in DS-ML blasts, leading to the manufacture of a truncated from a GATA1 truncated from of GATA1, according to gene characterization of DS-ML blasts. We previously developed a model for TAM by introducing disease-specific GATA1 mutation in trisomy 21-induced pluripotent stem cells, resulting in the production of a short form of GATA1. A member of the cohesin complex mutated in DS-ML but not in TAM, according to CRISPR/Cas9 to introduce a co-operating mutation in STAG2. The differentiation of GATA1 and the absence of functional STAG2 protein in the STAG1 genotype has been documented by GATA1's expression and the absence of functional STAG2 protein, contributing to the increased production of immature megakaryocytic cells relative to the GATA1 mutant alone; STAG2 double-mutant iPSC lines confirmed GATA1's expression and the absence of functional STAG2 protein, contributing to an increased production of immature megakary compared to the GATA1 hema t ietic differentiation of GATA1 mutant i mutant a karyo a i -mutant i a t i cyma cytic ietic i sp and the mutant i mosp;.

Source link: https://europepmc.org/article/MED/35203280

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions