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1918 Influenza Pandemic - Europe PMC

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Last Updated: 27 October 2022

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Racial Disparities in Mortality During the 1918 Influenza Pandemic in United States Cities.

The 1918 influenza pandemic caused a dramatic decline in non-White influenza and pneumonia mortality disparities in United States cities, against a backdrop of extreme socioeconomic inequality. We also discuss the likelihood that differing behavioural responses to the herald wave may have shielded non-White urban populations. We provide a comprehensive overview and analysis of racial disparities in mortality during the 1918 pandemic, as well as diseases that affect specific microbial agents' natural histories and the social histories of those they infect.

Source link: https://europepmc.org/article/MED/36124998


Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques.

Given that macaques are medically valid preclinical models of human immunology that have advanced the field of infectious disease treatment, a lethal pandemic influenza challenge model would provide a lethal platform for testing new influenza vaccine trials. We've infected rhesus macaques and Mauritian cynomolo virus with a high incidence of 1918 H1N1 influenza virus in these two countries, along with estimates of epidemiology and disease severity. Despite being infected with a high dose of 1918 influenza transmissible via many routes, rhesus macaques displayed no signs of disease, with only intermittent viral shedding. Infected with intrabronchial instillation, Cynomole macaques had mild signs of infancy, with disease severity varying depending on the infection dose. Affecting with a high dose of 1918 influenza distributed via several routes, pulmonary infiltrates, and elevated inflammatory cytokine levels, atypically inflammatory cytokine levels in macaques.

Source link: https://europepmc.org/article/MED/35924920

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions