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14-3-3 Protein - Europe PMC

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Last Updated: 10 November 2022

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Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.

Cancer metastasis is a significant cause of cancer-related mortality. Particularly in lung cancer, the most common cause of cancer mortality, there are strategies to minimize metastases. This report investigates if the absence of USP18 reduced lung cancer metastasis. Reduced lung cancer development, wound-healing, migration, and invasion as a result of decreased murine lung cancer metastases, with markedly reduced murine lung cancer metastases. The absence of USP18 regulation of 14-3-3-3-1B6 protein was restricted by a lack of USP18 in shRNA knock-down lung cancer cells. According to The Cancer Genome Atlas, a rise in lung adenocarcinomas and other cancers was attributed to an elevated 14-3-33% expression. Human lung cancer arrays and syngeneic murine lung cancer metastasis models were reported and extended using 14-3-3-u03b6 immunohistochemical assays and syngeneic murine lung cancer metastasis kits. engineered 14-3-3-3u03b6 downsw u03b6-downlines and 14-3-3-3 u03b6 rescue experiments that reversed migration and invasion inhibition led to a direct 14-3-3-3-3u03b6's role in determining lung cancer metastasis in lung cancer metastasis.

Source link: https://europepmc.org/article/MED/35387560


Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3.

Here we reveal that the penultimate residue Ser904 in CIP2A's C-terminus can be phosphorylated to form a binding site for the regulatory protein 14-3-3. Treatment of TNBC cells by FC-A treatment has resulted in the increased CIP2A's association with 14-3-3. The PPI stabilizer FC-A will attack 14 and 3-3-3 and CIP2A's C-terminus, delivering a new interface that could potentially be exploited to control CIP2A's C-terminus, according to We show that the composite interface between 14 and 3-3 and CIP2A's C-terminus, providing a new interface that could be used to control CIP2A's.

Source link: https://europepmc.org/article/MED/36255265

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions