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13-Hydroxyoctadecadienoic Acid - Crossref

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Last Updated: 10 June 2022

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The 15-lipoxygenase-1 product 13- S -hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells

"Peroxisome proliferator-activated receptors are nuclear receptors for linoleic and arachidonic acid metabolites. " NSAIDs block PPAR-u03b4 production in colon cancer cells, according to a NSAID. The mechanistic link between 15-LOX-1 and PPAR-u03b4 was previously unknown. 13- S HODE binds to PPAR-u03b4 protein, decreases PPAR-u03b4 activation, and down-regulates PPAR-u03b4 expression in colorectal cancer cells, according to our new analysis; t. ppAR-u03b4 regulation is a critical step in NSAID down-regulation of PPAR-u03b4 and the resulting induction of apoptosis.

Source link: https://doi.org/10.1073/pnas.1631086100


12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

"Protein kinase C isoenzymes are essential components of cell signaling. " We investigated the regulation of PKC-alpha in murine B16 amelanotic melanoma cells by the monohydroxy fatty acids 12-hydroxyeristotetraenoic acid [12-HETE] and 13-hydroxyoctadecadienoic acid [13-HODE]. In B16a cells, diacylglycerol and inositol trisphosphate exhibited a rapid rise in cell levels of diacylglycerol and inositol trisphosphate. "B16a cells were found with a high-affinity binding site for 12-HETE, and binding of 12-HETE to B16a cells was effectively blocked by 13-HODE. ".

Source link: https://doi.org/10.1073/pnas.92.20.9323


Differential cell growth/apoptosis behavior of 13-hydroxyoctadecadienoic acid enantiomers in a colorectal cancer cell line

Each metabolite is synthesized from linoleic acid, giving two enantiomeric forms for each metabolite. The aim was to investigate the effect of 13-HODE enantiomers on nondifferentiated Caco-2 cell proliferation/apoptosis. We find that 13-HODE decreases cell proliferation and DNA synthesis of nondifferentiated Caco-2 cells cultured with 10% fetal bovine serum, according to our findings. In addition, we found that 13-HODE but not 13-HODE is a ligand to PPARu03b3, confirming the presence of this nuclear receptor in 13-HODE operations. BLT receptor-mediated signals, as well as PGE 2 synthesis, are triggered by a 13-HODE interaction with BLT receptors, which promotes ERK and CREB signaling pathways, as well as PGE 2 synthesis. These results indicate that the proliferative effect of 13-HODE may be owing, in part, to COX pathway activation. Cell growth/apoptosis was also found by these distinct effects of 9-HODE enantiomers on cell proliferation/apoptosis. "The microbial epithelium's balance between -HODEs and -HODEs could therefore be vital to cell formation/apoptosis homeostasis. ".

Source link: https://doi.org/10.1152/ajpgi.00064.2014

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions