12-Hydroxyheptadecatrienoic acid - DOAJ

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S]

12-hydroxyheptadeca-5Z,8 E,10E-trienoic acid has long been thought about a byproduct of thromboxane A2 biosynthesis with no organic task. During blood coagulation, 12-HHT degrees enhanced in a time-dependent manner and were fairly greater than those of TxB2, a secure metabolite of TxA2. Ozagrel-treated blood additionally displayed buildup of PGD2 and PGE2, possibly arising from the shunting of PGH2 into synthetic pathways for these prostaglandins. HEK293 cells transiently revealing TxAS along with cyclooxygenase -1 or COX-2 produced both TxB2 and 12-HHT from arachidonic acid, while HEK293 cells revealing just COX-1 or COX-2 generated substantial amounts of 12-HHT however no TxB2.

Source link: https://doi.org/10.1194/jlr.M037754

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